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US 2014/0271601 A1Published application
Crosslinkable trehalose for the covalent incorporation in hydrogels and methods of use
AssigneeInvivo Therapeutics Corporation
InventorsAlex A. Aimetti, Timothy M. O'Shea, Robert S. Langer, Xueqing Zhang
Life of this patent
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Abstract
Methods of controlled delivery of bioactive therapeutics are provided. Compositions comprising therapeutic implants are provided.
Claims57
A composition comprising:
- a trehalose containing hydrogel;
- and
- a therapeutic.
A trehalose containing hydrogel comprising:
- a first polymer, and
- a second polymer;
- wherein
- at least one of the first polymer or the second polymer includes trehalose covalently bound thereto.
1 more element
A composition comprising:
- a first polymer component having nucleophilic functional groups, a degree of functionality of greater than or equal to two, and is selected from the group consisting of a branched monomer, a multifunctional monomer, a branched polymer, and a multifunctional polymer,
- a second polymer component having electrophilic functional groups, a degree of functionality of greater than or equal to two and selected from the group consisting of a branched monomer, a multifunctional monomer, a branched polymer, and a multifunctional polymer,
- wherein, at least one of the first polymer component or the second polymer component includes crosslinkable trehalose.
The composition of claim 40, wherein n is equal to 2 or 3.
A composition comprising:
- a trehalose containing hydrogel, wherein the hydrogel includes a natural or synthetic polymer.
A kit comprising
- a first vessel containing:
- a first polymer component having nucleophilic functional groups, a degree of functionality of greater than or equal to two, and is selected from the group consisting of a branched monomer, a multifunctional monomer, a branched polymer, and a multifunctional polymer, and
- a second vessel containing:
- a second polymer component having electrophilic functional groups, a degree of functionality of greater than or equal to two and selected from the group consisting of a branched monomer, a multifunctional monomer, a branched polymer, and a multifunctional polymer;
- wherein, at least one of the first polymer component or the second polymer component includes crosslinkable trehalose.
2 more elements
A method of making a therapeutic implant comprising:
- inserting a crosslinkable trehalose polymer within a synthetic polymeric hydrogel to form a crosslinked hydrogel;
- and incorporating a therapeutic in the crosslinked hydrogel to form the therapeutic implant.
Dependencies are inferred from the claim text.