Compositions and methods for the modulation of hemoglobin (s)
AssigneeGlobal Blood Therapeutics, Inc.
InventorsUma Sinha, Brian W. Metcalf, Donna Oksenberg
Life of this patent
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Abstract
This invention provides pharmaceutical compositions for the allosteric modulation of hemoglobin (S) and methods for their use in treating disorders mediated by hemoglobin (S) and disorders that would benefit from tissue and/or cellular oxygenation.
Claims18
A composition comprising from about 1 mg to about 10 g of a compound selected from the group consisting of a compound in Table 1 and at least a pharmaceutically acceptable excipient, carrier or diluent.
A blood composition comprising blood and one or more compounds selected from the group consisting of a compound in Table 1,
- wherein said blood is comprised of red blood cells and plasma, and
- wherein at least 20% of said one or more compounds in the blood is bound to said red blood cells under physiological conditions.
A blood composition comprising an adduct formed from blood and one more or compounds selected from the group consisting of a compound in Table 1,
- wherein said blood is comprised of red blood cells and plasma,
- wherein said adduct is distributed under steady state conditions between a vascular space and an extra-vascular space in vivo, and
- wherein at least a portion of said one or more compounds remains in said vascular space as part of said adduct.
Dependencies are inferred from the claim text.