Treatment of inflammatory respiratory disease using biological solutions
AssigneeBiomet Biologics, LLC
InventorsMatthew D. LANDRIGAN, Krista O'SHAUGHNESSEY, Jennifer E. WOODELL-MAY
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Abstract
Methods and therapeutic compositions for treating respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and devices for administering the therapeutic compositions. Methods for treatment include producing a protein solution, producing a concentrated bone marrow aspirate (cBMA), optionally combining the protein solution and cBMA to form an therapeutic composition, and optionally saturating the autologous therapeutic composition with hydrogen gas, and administering the therapeutic composition to a subject in need thereof. The present methods, compositions and devices are useful for treating COPD and the progression of COPD.
Claims24
A method for treating respiratory disorder in a human or other mammalian subject, comprising topically administering a composition to the tissue at the site of the disorder in the subject, the composition comprising at least two proteins selected from the group consisting of IL-1ra, sTNF-RI, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-β1, and sIL-1RII, wherein the concentration of each protein in the composition is greater than the concentration of the protein in normal blood.
A method for treating chronic obstructive pulmonary disease in a human or other mammalian subject, comprising topically administering a composition to lung tissue of said subject, the composition comprising:
- (a) interleukin-1 receptor antagonist (IL-1ra), at a concentration at least 3 times greater than the concentration of IL-1ra in normal blood;
- (b) soluble tissue necrosis factor-r1 (sTNF-r1), at a concentration at least 2 times greater than the concentration of IL-1ra in normal blood;
- (c) white blood cells at a concentration at least 2 times greater than the concentration of white blood cells in normal blood;
- and
- (d) platelets, at a concentration at least 2 times greater than the concentration of platelets in normal blood.
A method for treating a respiratory disorder in a human or other mammalian subject, comprising topically administering a composition to the tissue at the site of the disorder in the subject a cell tissue material selected from the group consisting of bone marrow-derived mononuclear cells, platelets, bone marrow aspirate, concentrated bone marrow aspirate, adipose stromal cells, and combinations thereof.
Dependencies are inferred from the claim text.