Curcuminoid complexes with enhanced stability, solubility and/or bioavailability
AssigneeSouth Dakota Board of Regents
InventorsHemachand Tummala, Sunny Kumar
Life of this patent
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Abstract
Methods and materials relating to a medicament preparation comprising a curcuminoid component and a eudragit component provided as a curcuminoid-eudragit complex, which enhance the bioavailability of the curcumin component and are useful for the treatment of various diseases including cancer, neurodegeneration, inflammation, and immunodeficiency. In some aspects, the curcuminoid component comprises curcumin to prepare a curcumin-eudragit complex and a medicament comprising curcumin-eudragit complexes.
Claims25
A curcuminoid composition comprising:
- a curcuminoid component;
- and
- a eudragit component comprising a polymer or co-polymer having a backbone comprising polymethacrylate or methyl methacrylate;
- wherein the curcuminoid component and the eudragit component are in the form of a curcuminoid-eudragit complex.
A method of forming a plurality of particles comprising a curcuminoid-eudragit complex, the method comprising:
- dissolving at least one curcuminoid component and at least one eudragit component in an organic solvent to form a solution having the curcuminoid-eudragit complex, the eudragit component comprising a polymer or co-polymer having a backbone comprising polymethacrylate or methyl methacrylate;
- adding the solution containing the curcuminoid-eudragit complex to an aqueous solution to form the plurality of particles comprising the curcuminoid-eudragit complex;
- removing the organic solvent from the aqueous solution comprising the curcuminoid-eudragit complex particles;
- separating the curcuminoid-eudragit complex particles from the aqueous solution.
A medicament preparation providing enhanced curcuminoid stability, aqueous solubility and/or bioavailability, the medicament preparation comprising:
- a curcuminoid component and a eudragit component, the eudragit component comprising a polymer or co-polymer having a backbone comprising polymethacrylate or methyl methacrylate, wherein the curcuminoid component and the eudragit component are provided as a curcuminoid-eudragit complex, and wherein the curcuminoid-eudragit complex enhances a stability, an aqueous solubility and/or a bioavailability of the curcuminoid component compared to a free curcuminoid component when the curcuminoid component and the free curcuminoid component are the same curcuminoid component.
Dependencies are inferred from the claim text.