Nitric Oxide Releasing Multifunctional Polymers
AssigneeMaple Ridge Group, LLC
InventorsMichael Milbocker, Kenneth Rothaus
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Abstract
A molecule for stabilizing a bioactive chemical group capable of releasing nitric oxide in vivo is described. The molecule possesses multi-functionality, enabling the delivery of multiple nitric oxide precursors on a single molecule. In some embodiments, a tissue or prosthetic bonding group is attached to one of the functional arms of the molecule making the molecule of the present invention localizing to tissue or an implant.
Claims20
A nitric oxide releasing polymer comprising a biocompatible base polymer, at least one aromatic ring, and a NO-releasing group, wherein said biocompatible base polymer is attached to said aromatic ring through a urethane or urea link at one position on said aromatic ring, and said NO-releasing group is attached at another site.
A method of synthesizing a nitric oxide releasing polymer, comprising the steps of reacting a multi-functional alcohol with a diisocyanate until all hydroxyl functionality is consumed, to provide a macro multi-isocyanate;
- and then reacting said macro multi-isocyanate with gaseous nitric oxide until a portion of the isocyanate functionality of said macro multi-isocyanate is consumed.
Dependencies are inferred from the claim text.