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US 2014/0271492 A1Published application
Manufacturing Process for Effervescent Dosage Forms
OwnerTammy Bartleyinventor
Life of this patent
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Abstract
Methods of manufacturing effervescent dosage forms. Methods of manufacturing an effervescent tablet using a dry, direct compression process are disclosed. The methods do not result in the sticking of the mixture to be tableted to the punches during production.
Claims22
A method of formulating an effervescent dosage form, the method comprising:
- a) individually blending the acid and base components of an effervescent couple with a neutral, non-hygroscopic material to form a pre-blend acid component mixture and a pre-blend base component mixture;
- b) combining the pre-blend mixtures from step (a) with a mixture comprising an active pharmaceutical agent and optionally one or more excipients to form a final blend;
- and
- c) forming said final blend from step (b) into the effervescent dosage form.
1 more element
A method of preparing an effervescent dosage form, the method comprising the steps of:
- a) mixing a base component of an effervescent couple with a first non-hygroscopic material to form a pre-blend base component mixture;
- b) milling the pre-blend base component mixture to form a milled base component mixture;
- c) mixing an acid component of the effervescent couple with a second non-hygroscopic material to form a pre-blend acid component mixture;
- d) milling the pre-blend acid component mixture to form a milled acid component mixture;
- e) combining the milled base component mixture from (b) with a mixture comprising an active pharmaceutical agent to form an intermediate mixture;
- (d) combining the intermediate mixture with the milled acid component mixture from step (d) to form a final mixture;
- and
- d) forming said final mixture from step (c) into the effervescent dosage form.
5 more elements
A method of preparing an effervescent dosage form, the method comprising:
- a) mixing a base component of an effervescent couple with a non-hygroscopic material to form a pre-blend base component mixture.
A method of preparing an effervescent dosage form, the method comprising:
- a) mixing an acid component of an effervescent couple with a non-hygroscopic material to form a pre-blend acid component mixture.
Dependencies are inferred from the claim text.