Polymeric depots for localization of agent to biological sites
AssigneeTrustees of Boston University
InventorsMark W. Grinstaff, Aaron H. Colby, Yolonda Colson
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Abstract
Provided herein are polymeric particles and compounds and processes that can be used to prepare polymer-based particles and methods of using those particles to localize or concentrate a subsequently delivered agent to an in vivo site.
Claims21
A method of delivering, localizing or concentrating an agent to a tissue location in a subject, the method comprising administering to the subject an empty polymeric particle prior to, simultaneously with or after delivering an agent to the subject, wherein the empty polymeric particle undergoes a change in volume on contact with the tissue location and becomes lodged, embedded, immobilized or entrapped at the tissue location, and wherein the empty polymeric concentrates the agent at the tissue location.
2-44. (canceled)
The method of claim 53, wherein the oligomer or the polymer comprises the monomer
A method of treating a cancer or tumor in a subject, the method comprising administering to the subject in need thereof an empty polymeric particle prior to, simultaneously with or after administering an anti-cancer agent, wherein the empty polymeric particle undergoes a change in volume on contact with the tumor and becomes lodged, embedded, immobilized or entrapped in the tumor, and wherein the empty polymeric concentrates the anti-cancer agent in the tumor.
Dependencies are inferred from the claim text.