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US 2014/0271484 A1Published application
Methods of Imaging Inflammatory Diseases by Ligands Conjugated to Fluorescent Compounds
AssigneePurdue Research Foundation
InventorsPhilip S. Low, Sumith A. Kularatne, Lindsay E. Kelderhouse
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Abstract
The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods of imaging of inflammatory diseases using the compounds.
Claims29
A method of imaging an inflammatory disease comprising the steps of:
- a. administering to a patient in need of such a process an effective amount of a compound capable of binding to an inflammatory cell having the formula:
- or a pharmaceutically acceptable salt or isotope thereof, wherein:
- X is an amino acid or a derivative thereof, and
- Y is a dye that has a fluorescence excitation and emission spectra in the near infra red (NIR) range, and the compound maintains or enhances the fluorescence of the dye;
- and
- b. fluorescent imaging of an area of the inflammatory disease in the patient's body where the compound has been bound to an inflammatory cell.
3 more elements
A method of imaging an inflammatory disease comprising the step of:
- administering to a patient in need of such a process an effective amount of a compound capable of binding to an inflammatory cell having the formula
- wherein W, X, Y, Z each are H, Na, K+ or NH4+;
- and
- b. fluorescent imaging of an area of the inflammatory disease in the patient's body where the compound has been bound to an inflammatory cell.
1 more element
Dependencies are inferred from the claim text.