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US 2014/0271482 A1Published application
Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
AssigneePurdue Research Foundation
InventorsPhilip S. Low, Sumith A. Kularatne, Sakkarapalayam M. Mahalingam
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Abstract
The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
Claims69
A compound having the formula:
- or a pharmaceutically acceptable salt thereof,
- or isotopes thereof,
- wherein:
- X is an amino acid or a derivative thereof, and
- Y is a dye that has a fluorescence excitation and emission spectra in the near infra red range, and the compound maintains or enhances the fluorescence of the dye.
2 more elements
A compound having the formula:
- or a pharmaceutically acceptable salt thereof,
- or isotopes thereof,
- wherein:
- X an amino acid or a derivative thereof, and
- Y is a dye that has a fluorescence excitation in the visible spectrum and an emission spectra in the near infra red range, X is linked to Y creating a secondary amine directly attached to Y, and the compound maintains or enhances the fluorescence of the dye.
2 more elements
Dependencies are inferred from the claim text.