Methods and intermediates for preparing macrolactams
AssigneeMerck Sharp & Dohme Corp.
InventorsNobuyoshi Yasuda, Jeffrey T. Kuethe, Guy Humphrey, Gregory L. Beutner, Yong-Li Zhong, Edward Cleator, Carl Baxter
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Abstract
The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applica
Claims12
A compound selected from the group consisting of:
- wherein R is either H, acetyl, or C(O)NHCH(X)COOH, and X is a C2-C6 alkyl, or a C3-C8 cycloalkyl,
- and salts thereof, wherein Y is a protecting group or H.
A method of making Compound 6, comprising the step:
A method of making a compound of Formula I
- wherein R is C(O)NHCH(X)COOH, X is a C2-C6 alkyl, or a C3-C8 cycloalkyl;
- or a salt thereof;
- comprising the step of:
A method of producing Compound 5, comprising the step of:
- wherein PG is a protecting group.
A method of producing a compound comprising the step of:
- or salts thereof, wherein PG is a protecting group.
Dependencies are inferred from the claim text.