Transgenic Plants Resistant To Non-Protein Amino Acids
AssigneeYeda Research and Development Co. Ltd.
InventorsMark Safro, Liron Klipcan, Inbar Maymon, Igal Finarov
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Abstract
Transgenic plants resistant to bio-herbicides, particularly to phytotoxic non-protein amino acids including the meta-tyrosine (m-tyrosine) amino acid analog and salts thereof, means and methods for producing the transgenic plants.
Claims23
A transgenic plant comprising at least one cell comprising at least one exogenous polynucleotide encoding an aminoacyl tRNA synthase (aaRS) or a fragment thereof, the aaRS or fragment thereof comprising an editing module capable of hydrolyzing tRNA misacylated with non-protein amino acid analog, wherein the plant is resistant to the non-protein amino acid analog and salts thereof.
The transgenic plant of claim 3, wherein growth inhibition is shown by at least one of reduced root length, reduced root radical, reduced root mass, reduced plant height, aberrant change in a plant tissue morphology or color, reduced plant shoot mass, reduced plant shoot number and any combination thereof.
A method for producing a transgenic plant resistant to phytotoxic non-protein amino acid analog or a salt thereof, the method comprising the steps of:
- (a) transforming a plant cell with at least one exogenous polynucleotide encoding an aminoacyl tRNA synthetase (aaRS) or a fragment thereof the aaRS or fragment thereof comprising an editing module capable of hydrolyzing non-protein aminoacylated tRNA;
- and
- (b) regenerating the transformed cell into a transgenic plant resistant to the phytotoxic non-protein amino acid analog or a salt thereof.
Dependencies are inferred from the claim text.