Neurovirulent Strain of the West Nile Virus and Uses Thereof
AssigneesKimron Veterinary Institute, Institut Pasteur
InventorsDespres Philippe, Vincent Deubel, Jean-Louis Guenet, Marie-Therese Drouet, Mertyn Malkinson, Caroline Banet, Marie-Pascale Frenkiel, Marie-Pierre Courageot, Fasseli Coulibaly, Adeline Catteau, Marie Flamand, Patrick Weber, Pierre-Emmanuel Ceccaldi
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Abstract
Neuroinvasive and neurovirulent strain of the West Nile virus, named IS-98-ST1, nucleic acid molecules derived from its genome, proteins and peptides encoded by said nucleic acid molecules, and uses thereof.
Claims18
An isolated strain of the West Nile virus, characterized in that its genome consists of the sequence SEQ ID No. 1.
A nucleic acid molecule, characterized in that it is selected from the group consisting of the sequence SEQ ID No. 1, the fragments of at least 15 nucleotides of the sequence SEQ ID No. 1 and the sense and antisense sequences complementary to the above sequences, excluding the fragment having the GENBANK sequence AF205882.
A method for screening cellular genes involved in the resistance of a mammal to infection with a virus of the family Flaviviridae, characterized in that it comprises the following steps:
- culturing cells derived from a host (human or nonhuman) selected for its resistance or its sensitivity to infection with a Flaviviridae,
- infecting said cells with a Flaviviridae, in vitro, and
- detecting genes expressed differentially in said infected cells.
Dependencies are inferred from the claim text.