Multi-parameter thrombotic assay apparatus, systems, and methods

A method for exposing blood to multiple conditions to determine clot activity, comprising:

• exposing a specimen of blood to one or more blood conditions in vitro to form one or more blood samples;
• delivering the one or more blood samples into or through a plurality of test receptacles;
• and
• analyzing an amount of clot formation, if any, that occurs within each of the test receptacles,
• wherein:
• the one or more blood samples are delivered at a first blood flow rate through a first subset of the plurality of test receptacles and at a second blood flow rate which is different from the first blood flow rate through a second subset of the plurality of test receptacles,
• a third subset of the plurality of test receptacles have blood contacting surfaces which are coated with a first surface substrate, and
• a fourth subset of the plurality of test receptacles have blood contacting surfaces which are coated with a second surface substrate which is different from the first surface substrate.

A system for determining one or more thrombotic conditions of a patient, comprising:

• at least one memory that stores computer-executable instructions;
• and
• at least one processor configured to access the at least one memory, wherein the at least one processor is configured to execute the computer-executable instructions to:
• receive a plurality of patient data points from a device which exposes a sample of the patient's blood to multiple exposure conditions in vitro, each patient data point comprising an amount of clot formation and one or more exposure conditions;
• create a virtual multi-dimensional representation of the plurality of patient data points;
• and
• determine, based at least in part on the virtual multi-dimensional representation, one or more thrombotic conditions of the patient,
• wherein the exposure conditions comprise blood contacting surface substrate, chemical agent addition, and blood flow rate.

A method for determining one or more thrombotic conditions of a selected patient, comprising:

• receiving, by at least one processer configured to access at least one memory, a plurality of patient data points from a device which exposes a sample of the patient's blood to multiple exposure conditions in vitro, each patient data point comprising an amount of clot formation and one or more exposure conditions;
• creating, by the at least one processor, a virtual multi-dimensional representation of the plurality of patient data points;
• and
• determining, by the at least one processor, based at least in part on the virtual multi-dimensional representation of the plurality of patient data points, one or more thrombotic conditions of the patient,
• wherein the exposure conditions comprise blood contacting surface substrate, chemical agent addition, and blood flow rate.