Method and system for patient-specific modeling of blood flow

A system for determining cardiovascular information for a patient, the system comprising:

• at least one computer system configured to:
• receive patient-specific data regarding a geometry of an anatomical structure of the patient, the anatomical structure including at least a portion of one or more coronary arteries;
• create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data;
• determine a myocardial mass of the patient based on the patient-specific data;
• estimate total coronary blood flow of the patient based on the determined myocardial mass;
• create a reduced-order blood flow model relating to a blood flow characteristic within the portion of the anatomical structure based, at least in part, on the estimated total coronary blood flow and the three-dimensional model;
• and
• determine a value of a fractional flow reserve at each of a plurality of locations within the portion of the anatomical structure based on one or more solutions of the reduced-order blood flow model.

A method for determining patient-specific cardiovascular information using at least one computer system, the method comprising:

• receiving patient-specific data regarding a geometry of an anatomical structure of the patient, the anatomical structure including at least a portion of one or more coronary arteries;
• creating a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data;
• determining a myocardial mass of the patient based on the patient-specific data;
• estimating total coronary blood flow of the patient based on the determined myocardial mass;
• creating a reduced-order blood flow model relating to a blood flow characteristic within the portion of the anatomical structure based, at least in part, on the estimated total coronary blood flow and the three-dimensional model;
• and
• determining a value of a fractional flow reserve at each of a plurality of locations within the portion of the anatomical structure based on one or more solutions of the reduced-order blood flow model.

A system for determining cardiovascular information for a patient, the system comprising:

• at least one computer system configured to:
• receive patient-specific data regarding a geometry of an anatomical structure of the patient, the anatomical structure including at least a portion of one or more coronary arteries;
• create a first model, in three dimensions, representing a portion of the anatomical structure of the patient based on the patient-specific data;
• determine a myocardial mass or total coronary blood flow of the patient based on the patient-specific data;
• create a second model, based on one or more fluid dynamics equations, relating to fluid flow within the portion of the anatomical structure based on, at least in part, the determined myocardial mass or total coronary blood flow;
• and
• determine a value of a blood flow characteristic at each of a plurality of locations of the portion of the anatomical structure based on one or more solutions of the fluid dynamics equations.

A system for determining cardiovascular information for a patient, the system comprising:

• at least one computer system configured to:
• receive patient-specific data regarding a geometry of an anatomical structure of the patient, the anatomical structure including at least a portion of one or more coronary arteries;
• create a three-dimensional model representing at least a portion of one or more coronary arteries based on the received patient-specific data, the three-dimensional model representing at least one fluid flow inlet and at least one fluid flow outlet;
• create at least one boundary condition model representing fluid flow through at least one of the at least one inlet or the at least one outlet, wherein the at least one boundary condition model has fewer than three dimensions;
• and
• determine a value of a fractional flow reserve at each of a plurality of locations of the one or more coronary arteries based on the three-dimensional model, and by solving one or more equations associated with the boundary condition model.