Cortical bone scaffold for guided osteon regeneration in load-bearing orthopaedic applications
OwnerMark R. Appleford, Marcello Piliainventors
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Abstract
Described is an artificial bone scaffold with an architecture resembling cortical bone, including microchannel-like structures resembling osteons. The scaffold enhances the ability of osteoblasts to secrete organized collagen and mineralize extracellular matrix within the osteon-like channels, thus promoting scaffold strength.
Claims17
A method of forming a scaffold for the repair of load-bearing bone damage comprising:
- obtaining a mold having an interior space that is complementary to the bone repair site;
- coupling wires to the mold, such that the wires extend through an interior space of the mold
- placing a fluid composition of hydroxyapatite and β-tricalcium phosphate into the interior space of the mold;
- wherein the fluid composition surrounds at least a portion of the wires;
- removing the wires from the mold after the fluid composition hardens.
A bone scaffold for the repair of load-bearing bone damage comprising hydroxyapatite and β-tricalcium phosphate, wherein the scaffold has an architecture that matches the structure of cortical bone.
A mold for forming a bone scaffold for the repair of load-bearing bone damage, comprising:
- a body having an interior surface, wherein the interior surface defines the shape of the scaffold;
- a top plate and a bottom plate, couplable to a top end and a bottom end of the body, wherein the top plate and the bottom plate each comprise a plurality of openings, wherein, during formation of the scaffold, one of more wires are placed in the openings.
Dependencies are inferred from the claim text.