Photosensitive cardiac rhythm modulation systems
AssigneePresident and Fellows of Harvard College
InventorKevin Kit Parker
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Abstract
Photosensitive cardiac rhythm modulation structures and systems are described. A genetically-engineered tissue comprising a population of pacing cells expressing a photosensitive membrane transport mechanism that is responsive to light of a particular wavelength(s) combined with one or more of a light source, a power generator, and a sensor provides pacemaker and/or defibrillator function to a subject. The systems further provide in vitro model systems for electrophysiological studies.
Claims25
A genetically engineered photosensitive tissue, comprising a population of pacing cells expressing a photosensitive membrane transport mechanism.
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A method of treating cardiac dysfunction in a subject in need thereof, comprising
- contacting a pacing cell of the subject with a nucleic acid molecule comprising a photosensitive membrane transport mechanism;
- and
- photostimulating the genetically engineered photosensitive tissue, thereby treating cardiac dysfunction in the subject.
Dependencies are inferred from the claim text.