US 2014/0236256 A1 · SYSTEM FOR SETTING PROGRAMMABLE PARAMETERS FOR AN IMPLANTABLE HYPERTENSION TREATMENT DEVICE

Abstract

A real time, heart rate monitor and a hemodynamic monitoring system are operably integrated with the programmer system for an implantable hypertension treatment device. A series of tests are automatically performed to set programmable parameters for the implantable hypertension treatment device without clinician intervention. In one embodiment, a predetermined level of a dose-response evaluation is initiated for each test in the series. Preferably, the programmer system monitors the heart rate to determine whether a hemodynamic measurement should be initiated at all for a given test, as well as whether the hemodynamic measurement should be initiated earlier or later than a predetermined settling period for assessing the sympathetic nervous response to the test dose. In one embodiment, this determination is based on heart rate stability/instability. Alternatively, other indicators of sympathetic/parasympathetic tone, such as heart rate variability, may be used to trigger/delay the timing of the hemodynamic measurement.

Claims21

Dependent claims

1-20. (canceled)

A system for setting programmable parameters for an implantable baroreflex stimulation device, comprising:

an implantable baroreflex stimulation device including an electrode configured to be implanted on or in a blood vessel proximate one or more baroreceptors in a wall of the blood vessel;
and
a programming system communicatively interfaced with the implantable baroreflex stimulation device and with a hemodynamic monitoring system configured to collect information representing a hemodynamic response of the patient over a monitoring time duration, the programming system being configured to:
cause the implantable baroreflex stimulation device to initiate an electrotherapy dose-response test, the test including:
delivering a plurality of electrotherapy doses of varying levels to the one or more baroreceptors of the patient via the electrode;
and
for each electrotherapy dose, selectively processing the information representing the hemodynamic response of the patient for the monitoring time duration for that electrotherapy dose to establish a patient-specific electrotherapy dose response relationship between the electrotherapy dose and the hemodynamic response of the patient;
program the implantable baroreflex stimulation device with at least one operating parameter based at least in part on the patient-specific electrotherapy dose-response relationship subsequent to establishing the patient-specific electrotherapy dose-response relationship.

5 more elements

A method of establishing programmable parameters for an implantable baroreflex stimulation device in a patient comprising:

providing a programming system that is configured to perform the steps of:
causing the implantable baroreflex stimulation device to initiate an electrotherapy dose-response test, the test including:
delivering a plurality of electrotherapy doses of varying levels to one or more baroreceptors of the patient via an electrode implanted on or in a blood vessel proximate the one or more baroreceptors in a wall of the blood vessel;
monitoring information representing a hemodynamic response of the patient over a monitoring time duration for each of the plurality of electrotherapy doses;
and
establishing a patient-specific electrotherapy dose response relationship between the electrotherapy dose and the hemodynamic response;
using the programming system to program the implantable baroreflex stimulation device with at least one operating parameter based at least in part on the patient-specific electrotherapy dose-response relationship subsequent to establishing the patient-specific electrotherapy dose-response relationship.

4 more elements

Dependencies are inferred from the claim text.

System for setting programmable parameters for an implantable hypertension treatment device

Life of this patent

System for setting programmable parameters for an implantable hypertension treatment device

Life of this patent

Abstract

Claims21