Method and system for quantitative vectorial perfusion based upon blood flow direction using 4d medical imaging
AssigneesToshiba Medical Systems Corporation, Kabushiki Kaisha Toshiba
InventorNicolas ROGNIN
Life of this patent
Estimating the term…
Abstract
A tissue response in a predetermined unit of volume or area tissue of interest is determined by excluding some data of the adjacent tissues based upon a blood flow direction with respect to the tissue of interest. The exclusion is based upon a predetermined time-related parameter such as time-to-peak and mean-transit time in the fitted curves of the uptake of a contrast agent in the adjacent tissues and the tissue of interest. Furthermore, the blood flow direction is determined in terms of a 3D vector based upon a plurality of weighted individual vectors from the adjacent or neighboring voxels with respect to the voxel of interest.
Claims23
A method of determining a tissue perfusion response, comprising:
- perfusing a predetermined contrast agent into a subject;
- acquiring data using a predetermined modality as a function of time;
- determining a time-related parameter value based upon the acquired data for each of a predetermined set of voxels consisting of adjacent voxels and at least one voxel of interest;
- excluding some of the acquired data corresponding to any one of the adjacent voxels based upon the time-related parameter value along a predetermined blood flow direction to the voxel of interest, the remaining acquired data defining selected adjacent voxels;
- determining a local input function based the acquired data of the selected adjacent voxels;
- and
- determining the tissue perfusion response based upon the local input function and an output function according to the acquired data.
A method of determining a tissue perfusion response using ultrasound, comprising:
- perfusing predetermined microbubbles into a subject;
- acquiring data using contrast ultrasound;
- applying a predetermined curve fitting technique to the acquired data to obtain a plurality of fitted curves for a predetermined set of voxels consisting of adjacent voxels and at least one voxel of interest;
- determining a time-to-peak parameter value based upon the fitted curves for each of the voxels;
- excluding any one of the fitted curves corresponding to the adjacent voxel if the time-to-peak parameter value of the adjacent voxel exceeds the time-to-peak parameter value of the voxel of interest to define selected adjacent voxels based upon remaining ones of the fitted curves along a predetermined direction to the voxel of interest;
- determining a local input function by adding the fitted curves from the selected adjacent voxels;
- and
- determining the tissue perfusion response based upon the local input function and an output function according to the acquired data.
A system for determining a tissue perfusion response, comprising:
- a perfusion unit for perusing a predetermined contrast agent into a subject;
- a data acquiring unit for acquiring data using a predetermined modality as a function of time;
- and
- a processing unit connected to said data acquiring unit for determining a time-related parameter value based upon the acquired data for each of a predetermined set of voxels consisting of adjacent voxels and at least one voxel of interest, said processing unit excluding any one of the adjacent voxel based upon the time-related parameter value along a predetermined blood flow direction to the voxel of interest to define selected adjacent voxels, said processing unit determining a local input function based the acquired data of the selected adjacent voxels, said processing unit determining the tissue perfusion response based upon the local input function and an output function according to the acquired data.
A system for determining a tissue perfusion response using ultrasound, comprising:
- a perfusion unit for perfusing predetermined microbubbles into a subject;
- a data acquiring unit for acquiring data using contrast ultrasound;
- and
- a processing unit connected to said data acquiring unit for applying a predetermined curve fitting technique to the acquired data to obtain a plurality of fitted curves for a predetermined set of voxels consisting of adjacent voxels and at least one voxel of interest, said processing unit determining a time-to-peak parameter value based upon the fitted curves for each of the voxels, said processing unit excluding any one of the fitted curves corresponding to the adjacent voxel if the time-to-peak parameter value of the adjacent voxel exceeds the time-to-peak parameter value of the voxel of interest to define selected adjacent voxels based upon remaining ones of the fitted curves, said processing unit determining a local input function by adding the fitted curves from the selected adjacent voxels, said processing unit determining the tissue perfusion response based upon the local input function and an output function according to the acquired data.
Dependencies are inferred from the claim text.