Integrated calibrant measurement system for analyte sensors

A blood sensing system for sensing an analyte concentration of a patient's blood using a calibrant, the blood sensing comprising:

• a blood sensor configured to generate a blood signal in response to exposure to the patient's blood;
• a calibration system connected in communication with the blood sensor, and configured to record a calibration signal from the blood sensor in response to exposure to the calibrant;
• and
• a calibrant concentration measurement system connected in communication with the calibration system and the blood sensor, the calibrant concentration measurement system including a calibrant sensor configured to measure a calibrant concentration in response to exposure to the calibrant,
• wherein the calibrant concentration measurement system is further configured to use the calibrant concentration, calibration signal and the blood signal to determine the analyte concentration of the patient's blood.