Method for making a precursor of l-fucose from d-glucose
AssigneeGlycom A/S
InventorsJulien BOUTET, Nikolay KHANZHIN, Filippo BONACCORSI, Gyula DEKANY
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Abstract
A method that can be used to make a precursor of L-fucose from D-glucose that includes the steps of a) making a compound of formula (1) from D-glucose, formula (1) wherein R1 is acyloxy, and Q is a group (a), (b), (c) or (d), formula (a), (b), (c) or (d) or wherein R1 is OH, and Q is a group (e), (f) or (g); formula (e), (f) or (g) wherein R2 is acyloxy and R3 is a sulphonyl leaving group; and b) producing 6-deoxy-L-talose from the compound of formula (1) formed in step a), wherein the moiety is a highly lipophilic protecting group; compounds according to formula (1), and use of a compound according to formula (1) are provided.
Claims31
A method that can be used to make a precursor of L-fucose from D-glucose, that comprises the steps of:
- a) making a compound of formula 1 from D-glucose,
- wherein R1 is acyloxy, and Q is a group (a), (b), (c) or (d),
- or wherein R1 is OH, and Q is a group (e), (f) or (g)
- wherein R2 is acyloxy and R3 is a sulphonyl leaving group;
- and
- b) producing 6-deoxy-L-talose from the compound of formula 1 formed in step a),
- wherein the moiety
- is a highly lipophilic protecting group.
(canceled)
Dependencies are inferred from the claim text.