Immunologic Constructs and Methods
AssigneeVaxInnate Corporation
InventorsLangzhou Song, Ge Liu, Scott Umlauf, Uma Kavita, Hong Li, Xiangyu Liu, Bruce Weaver, Lynda Tussey
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Abstract
The present invention relates to improved vaccines and the design and making of such vaccines that enhance immunogenicity of the vaccine and/or reduce reactogenicity to the vaccine when administered. In particular the vaccines and immunogenic compositions of the present invention relate to flagellin-antigen fusion proteins in which the spatial orientation of the flagellin to antigen and the charge distribution of the antigen is optimized to enhance immunogenicity and/or reduce reactogenicity and/or improve folding of the protein.
Claims20
An immunologic fusion protein comprising flagellin and HA linked together by a linker wherein the HA has been modified such that its core residues within the interior of the HA head domain is less hydrophobic than wild-type HA and the surface of the HA has been modified to have a lower pI.
An immunologic fusion protein comprising flagellin and HA linked together by a linker wherein the HA has been modified such that its core residues within the interior of the HA head domain is less hydrophobic than wild-type HA.
An immunologic fusion protein comprising flagellin and HA linked together by a linker wherein the HA has been modified such that the pI of the HA is reduced.
An immunologic fusion protein comprising flagellin and HA linked together by a linker wherein the linker comprises two negatively charged amino acids.
Dependencies are inferred from the claim text.