Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
AssigneeAmgen Inc.
InventorsSimon Mark Jackson, Nigel Pelham Clinton Walker, Derek Evan Piper, Wenyan Shen, Chadwick Terence King, Randal Robert Ketchem, Christopher Mehlin, Teresa Arazas Carabeo
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Abstract
Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
Claims30
(canceled)
An isolated monoclonal antibody that binds to an epitope, wherein the epitope includes at least one of amino acid residues 311 to 313 of SEQ ID NO:
- 1.
An isolated monoclonal antibody that binds to human PCSK9 having an amino acid sequence of SEQ ID NO:
- 1 at one or more of amino acid residues 311-313 of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.