Particles coated with zwitterionic polymers
AssigneeUniversity of Washington
InventorsShaoyi Jiang, Shengfu Chen, Yung Chang, Zheng Zhang
Life of this patent
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Abstract
Nanoparticles zwitterionic polymers grafted thereto or grafted therefrom, and methods for making and using the nanoparticles. Zwitterionic nanogels, and methods for making and using the nanogels.
Claims19
A surface having a layer of sulfobetaine polymers coupled thereto, wherein the density of the sulfobetaine polymers in the layer provides a surface having a fibrinogen adsorption of less than about 30 ng/cm2 in a fibrinogen binding assay when the surface is incubated at 37° C. for 90 minutes with a 1.0 mg/mL fibrinogen solution (0.15 M phosphate buffered saline at pH 7.4).
A substrate comprising a surface having a layer of sulfobetaine polymers grafted from the surface, wherein the density of the sulfobetaine polymers in the layer provides a surface having a fibrinogen adsorption of less than about 30 ng/cm2 in a fibrinogen binding assay when the surface is incubated at 37° C. for 90 minutes with a 1.0 mg/mL fibrinogen solution (0.15 M phosphate buffered saline at pH 7.4).
Dependencies are inferred from the claim text.