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US 2014/0235702 A1Published application
Small molecule inhibitors of mcl-1 and the uses of thereof
AssigneesWayne State University, The Regents of the University of Michigan
InventorsZaneta Nikolovska-Coleska, Hollis D. Showalter, Chenzhong Liao, Ramzi Mohammad, Fardokht Abulwerdi
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Abstract
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having sulfonamido-1-hydroxynaphthalene structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.
Claims20
-32. (canceled)
A compound having Formula I:
- Formula II:
- or Formula III:
- including pharmaceutically acceptable salts, solvates, and/or prodrugs thereof;
- wherein R1, R2, R3, m, n, X, Y, Z and ZZ independently include any chemical moiety that permits the resulting compound to bind with an Mcl-1 protein.
1 more element
Dependencies are inferred from the claim text.