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US 2014/0235699 A1Published application
Adeno-parvovirus chimera with enhanced oncolytical potential
AssigneeDeutsches Krebsforschungszentrum
InventorsNazim El-Andaloussi, Antonio Marchini, Jean Rommelaere
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Abstract
Described is a chimerical adenovirus-parvovirus vector characterized in that it comprises the entire parvovirus genome inserted into a adenovirus genome, wherein: (a) the adenovirus genome is characterized by deletion of E1 and E3, and (b) the biological activity of the parvoviral protein NS, preferably NS1, is reduced or eliminated.
Claims24
A chimeric adeno-parvovirus vector characterized in that it comprises the entire parvovirus genome inserted into an adenovirus genome, wherein:
- (a) the adenovirus genome is characterized by deletion of E1 and E3;
- and
- (b) the activity of at least the parvoviral protein NS is repressed or blocked in the packaging cell line during chimera production but is fully functional in cancer cells.
Dependencies are inferred from the claim text.