Stable Preservative-free Mydriatic and Anti-inflammatory Solutions for Injection
AssigneeOmeros Corporation
InventorsGregory A. Demopulos, Hui-rong Shen, Clark E. Tedford
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Abstract
The present invention relates to stable, preservative- and antioxidant-free liquid formulations of phenylephrine and ketorolac for injection.
Claims27
A sterile liquid pharmaceutical formulation comprising phenylephrine, ketorolac and a buffer system in an aqueous carrier, wherein the formulation is preservative-free and antioxidant-free and is stable for at least six months when stored at a temperature of from 5+/−3° C. to 25+/−2° C.
A sterile liquid pharmaceutical formulation consisting essentially of phenylephrine, ketorolac and a buffer system in an aqueous carrier, wherein the formulation is stable for at least six months when stored at a temperature of from 5+/−3° C. to 25+/−2° C.
A sterile liquid pharmaceutical dosage form for injection, comprising phenylephrine, ketorolac, a buffer system and an aqueous carrier packaged in a single-use container for injection.
A sterile liquid pharmaceutical formulation comprising phenylephrine, ketorolac, a buffer system and an intraocular irrigation carrier, wherein the phenylephrine is included at a concentration of from 30 to 720 μM and the ketorolac is included at a concentration of from 10 to 270 μM.
Dependencies are inferred from the claim text.