Scriptaid isosteres and their use in therapy
AssigneeKarus Therapeutics Limited
InventorsStephen Joseph SHUTTLEWORTH, Cyrille Davy TOMASSI
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Abstract
Compounds of the invention are of the formula wherein: is a double bond and X is C; or is a single bond and X is N, CH or CQR1; and wherein: n is 1 to 10; R is H or QR1; each R′ is independently selected from H and QR1; each Q is independently selected from a bond, CO, NH, S, SO, SO2 or O; each R1 is independently selected from C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, substituted or unsubstituted aryl or heteroaryl, acyl, C1-C10 cycloalkyl, halogen, C1-C10 alkylaryl or C1-C10 heterocycloalkyl; L is a nitrogen-containing heteroaryl; and W is a zinc-chelating residue; or a pharmaceutically acceptable salt thereof. The compounds are useful in therapy.
Claims19
A compound of the formula
- wherein:
- . . . is a double bond and X is C;
- or
- . . . is a single bond and X is N, CH or CQR1;
- and
- wherein:
- n is 1 to 10;
- R is H or QR1;
- each R′ is independently selected from H and QR1;
- each Q is independently selected from a bond, CO, NH, S, SO, SO2 and O;
- each R1 is independently selected from C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, heteroaryl, acyl, C1-C10 cycloalkyl, halogen, C1-C10 alkylaryl and C1-C10 heterocycloalkyl;
- L is a nitrogen-containing heteroaryl;
- W is a zinc-chelating residue;
- and
- wherein each of the R1 and L groups can be optionally substituted,
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.