Compounds and compositions as selective estrogen receptor degraders

A compound of formula I:

• in which:
• n is selected from 0, 1 and 2;
• m is selected from 0, 1 and 2;
• X is selected from O and NR6;
• wherein R6 is C1-4alkyl;
• Y1 is selected from N and CR7;
• wherein R7 is selected from hydrogen and C1-4alkyl;
• R1 is hydrogen;
• R2 is selected from hydrogen and halo;
• R3 is selected from —CH2CH2R8b and —CR8a═CR8aR8b;
• wherein each R8a is independently selected from hydrogen, fluoro and C1-4alkyl;
• and R8b is selected from —C(O)OR9a, —C(O)NR9aR9b, —C(O)NHOR9a, —C(O)X2R9a and a 5-6 member heteroaryl selected from:
• wherein the dotted line indicates the point of attachment with —CH2CH2 or —CR8a═CR8a of R3;
• wherein X2 is C1-4alkylene;
• R9a and R9b are independently selected from hydrogen, C1-4alkyl, hydroxy-substituted-C1-4alkyl and halo-substituted-C1-4alkyl;
• wherein said heteroaryl of R8b is unsubstituted or substituted with a group selected from C1-4alkyl and C3-8cycloalkyl;
• R4 is selected from hydrogen, C1-4alkyl, halo and C1-3alkoxy;
• R5 is selected from C6-10aryl and a 5-6 member heteroaryl selected from:
• wherein the dotted line indicates the point of attachment with the benzothiophene core;
• wherein said C6-10aryl or heteroaryl of R5 is substituted with 1 to 3 R5a groups independently selected from hydroxy, amino, C1-4alkyl, halo, nitro, cyano, halo-substituted-C1-4alkyl, cyano-substituted-C1-4alkyl, hydroxy-substituted-C1-4alkyl, halo-substituted-C1-4alkoxy, C1-4alkoxy, —SF5, —NR11aR11b, —C(O)R11a and a 4-7 member saturated ring containing one other heteroatom or group selected from O, NH, and S(O)0-2;
• wherein R11a and R11b are independently selected from hydrogen and C1-4alkyl;
• or R11a and R11b together with the nitrogen to which they are both attached form a 4 to 7 member saturated ring containing one other heteroatom or group selected from O, NH, and S(O)0-2;
• wherein said 4-7 member ring of R5a can be unsubstituted or substituted with C1-4alkyl;
• or a pharmaceutically acceptable salt thereof.