Delta-tocotrienol treatment and prevention of pancreatic cancer
AssigneeUniversity of South Florida
InventorsMokenge P. Malafa, Said M. Sebti
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Abstract
Methods are disclosed for treating neoplastic disorders, such as pancreatic cancer, using tocotrienols; namely, gamma-tocotrienol and delta tocotrienol. The antitumorogenic effects of these compounds are shown both in vitro and in vivo using several human pancreatic cancer cell lines and MIA-PACA2 human pancreatic cancer cells xenografted in nude mice. Also disclosed are methods of testing the efficacy of potential chemotherapeutic agents by measuring their effect on surrogate endpoint biomarkers, such as Ki-67 and p27. Associated compounds are also disclosed.
Claims16
A method of treating pancreatic cancer, comprising administering to a subject a composition comprising a therapeutically effective amount of at least one tocotrienol, wherein the tocotrienol is delta-tocotrienol and at least one chemotherapeutic agent, wherein the chemotherapeutic agent is 5-Fluorouracil.
Dependencies are inferred from the claim text.