Piperazine derivatives, methods for preparing same, and uses thereof in the treatment of insulin resistance

Compound of formula (I)

• in which:
• R1 represents:
• a —C(O)CR3R4CR5R6C(O)OH group;
• a —C(OH)(H)CR3R4CR5R6C(O)OH group;
• or
• a group
• n represents 0 or 1;
• m represents an integer ranging from 0 to 8;
• L1 represents a —C(O)—;
• —C(O)O— or —S(O)2— group;
• R2 represents:
• a carbocycle group with 5, 6 or 7 members, saturated, partially unsaturated or aromatic, substituted or non-substituted;
• a polycarbocycle group with 8 to 14 members, saturated, partially unsaturated or aromatic, substituted or non-substituted;
• a heterocycle group with 5, 6 or 7 members, substituted or non-substituted, saturated, partially unsaturated or aromatic, comprising 1, 2 or 3 heteroatoms, identical or different;
• a polyheterocycle group with 8 to 14 members, substituted or non-substituted, saturated, partially unsaturated or aromatic, comprising 1, 2 or 3 heteroatoms identical or different;
• a -L2-carbocycle group, the carbocycle being in 5, 6 or 7 members, saturated, partially unsaturated or aromatic, substituted or non-substituted;
• a -L2-polycarbocycle, the polycarbocycle being in 8 to 14 members, saturated, partially unsaturated or aromatic, substituted or non-substituted;
• a -L2-heterocycle group, the heterocycle being in 5, 6 or 7 members, substituted or non-substituted, saturated, partially unsaturated or aromatic and comprising 1, 2 or 3 heteroatoms, identical or different;
• a -L2-polyheterocycle group, the polyheterocycle being in 8 to 14 members, substituted or non-substituted, saturated, partially unsaturated or aromatic and comprising 1, 2 or 3 hetero atoms, identical or different;
• or
• a hydrocarbon group, linear or branched, C1 to C5;
• L2 represents an alkyl, linear or branched, C1 to C5;
• R3, R4, R5 and R6, identical or different, represent:
• a hydrogen atom;
• an alkyl group, linear or branched, C1 to C5;
• a carbocycle group with 5, 6 or 7 members, saturated, partially unsaturated or aromatic, substituted or non-substituted;
• or R3 and R4 form together with the carbon atom to which they are bonded a carbocycle with 5, 6 or 7 members, substituted or non-substituted;
• or R5 and R6 form together with the carbon atom to which they are bonded a carbocycle with 5, 6 or 7 members, substituted or non-substituted;
• or
• R7, identical or different, represent:
• an alkyl, linear or branched, C1 to C5;
• a -L2-carbocycle group, the carbocycle being in 5, 6 or 7 members, saturated, partially unsaturated or aromatic, substituted or non-substituted;
• a -L2-polycarbocycle, the polycarbocycle being in 8 to 14 members, saturated, partially unsaturated or aromatic, substituted or non-substituted;
• a -L2-heterocycle group, the heterocycle being in 5, 6 or 7 members, substituted or non-substituted, saturated, partially unsaturated or aromatic and comprising 1, 2 or 3 heteroatoms, identical or different, in particular chosen from nitrogen, oxygen or sulphur;
• or
• a -L2-polyheterocycle group, the polyheterocycle being in 8 to 14 members, substituted or non-substituted, saturated, partially unsaturated or aromatic and comprising 1, 2 or 3 heteroatoms, identical or different, in particular chosen from nitrogen, oxygen or sulphur;
• isomers, enantiomers and diastereoisomers thereof and the addition salts thereof with pharmaceutically acceptable bases or acids.