US 2014/0235641 A1Published application

Pyrazole carboxamides as janus kinase inhibitors

AssigneeMerck Sharp & Dohme Corp.

InventorsJason Brubaker, Joshua Close, Tony Siu, Graham Frank Smith, Luis E. Torres, Hyun Chong Woo, Jonathan R. Young, Zhongyong Wei, Feng Shi

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Abstract

The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Claims20

Dependent claims

A compound of formula I or a pharmaceutically acceptable salt or stereoisomer thereof:

Ra and R4 are each independently chosen from hydrogen and C1-4alkyl;
n is 0, 1, 2, 3, or 4;
p is 2, 3, or 4;
X is independently chosen from C, N, S, and O, wherein at least one X is other than carbon;
A is chosen from aryl, and heteroaryl;
R2 and R3 are each independently selected from:
hydrogen,
halogen,
C1-10 alkyl,
C2-10 alkenyl,
C1-10 heteroalkyl,
aryl C0-10 alkylC0-10 alkyl,
C3-8 cycloalkylC0-10 alkyl,
heteroaryl C0-10 alkyl,
(C3-8)heterocycloalkyl C0-10 alkyl,
wherein each of R2 and R3 are independently substituted with 0, 1, 2, 3, or 4, substituents R5a;
R5a is selected from:
hydrogen,
halogen,
C1-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
C1-10 heteroalkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
C2-10 alkenyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
aryl C0-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
aryl C2-10 alkenyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
aryl C2-10 alkynyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
C3-8 cycloalkyl C0-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
heteroaryl C0-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
(C3-8)heterocycloalkyl C0-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
C1-10 alkyl(carbonyl)0-1oxyC0-10 alkyl,
C1-10 heteroalkyl(carbonyl)0-1oxyC0-10 alkyl,
C2-10 alkenyl(carbonyl)0-1oxyC0-10 alkyl,
C1-10 heteroalkyl(carbonyl)0-1oxyC0-10 alkyl,
aryl C0-10 alkyl(carbonyl)0-1oxyC0-10alkyl,
(C3-8)cycloalkyl C0-10 alkyl(carbonyl)0-1oxyC0-10 alkyl,
heteroarylC0-10 alkyl(carbonyl)0-1oxyC0-10 alkyl,
(C3-8)heterocycloalkyl C0-10 alkyl(carbonyl)0-1oxyC0-10 alkyl,
((C0-10)alkyl)1-2aminocarbonyloxy,
(C0-10)heteroalkylaminocarbonyloxy,
aryl(C0-10)alkylaminocarbonyloxy,
(C3-8)cycloalkyl(C0-10)alkylaminocarbonyloxy,
heteroaryl(C0-10)alkylaminocarbonyloxy,
(C3-8)heterocycloalkyl(C0-10)alkylaminocarbonyloxy,
C1-10 alkylamino(oxy)0-1carbonylC0-10 alkyl,
(C0-10)heteroalkylamino(oxy)0-1carbonylC0-10 alkyl,
C3-8 cycloalkyl C0-10 alkylamino(oxy)0-1carbonylC0-10 alkyl,
aryl C0-10alkylamino(oxy)0-1carbonylC0-10 alkyl,
heteroarylC0-10alkylamino(oxy)0-1carbonylC0-10 alkyl,
(C3-8)heterocycloalkylC0-10alkylamino(oxy)0-1carbonylC0-10 alkyl,
C1-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
C1-10 heteroalkyl(oxy)0-1carbonylaminoC0-10 alkyl,
C3-8 cycloalkyl C0-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
aryl C0-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
heteroaryl C0-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
(C3-8)heterocycloalkyl C0-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
—CO2(C0-10 alkyl),
—(C0-10 alkyl)CO2H,
Oxo (═O),
C1-10 alkylsulfonyl,
C1-10 heteroalkylsulfonyl,
(C3-8)cycloalkylsulfonyl,
(C3-8)cycloheteroalkylsulfonyl,
heteroarylsulfonyl,
arylsulfonyl,
aminosulfonyl,
—SO2N(C1-6alkyl)1-2,
—SO2C1-6alkyl,
—SO2CF3,
—SO2CF2H,
C1-10 alkylsulfinyl,
amino,
(C0-10 alkyl)1-2 amino,
C1-4 acylamino C0-10 alkyl,
hydroxy,
C0-10 alkylalkoxy,
cyano,
C1-6 alkylcyano, and
C1-6 haloalkyl;
wherein R5a is each optionally substituted with 0, 1, 2, 3, or 4 substituents, R6, independently selected from:
halogen,
C1-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
C1-10 heteroalkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
C2-10 alkenyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
aryl C0-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
aryl C2-10 alkenyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
aryl C2-10 alkynyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
C3-8 cycloalkyl C0-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
heteroaryl C0-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
(C3-8)heterocycloalkyl C0-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
C1-10 alkyl(carbonyl)0-1oxyC0-10 alkyl,
C2-10 alkenyl(carbonyl)0-1oxyC0-10 alkyl,
C1-10 heteroalkyl(carbonyl)0-1oxyC0-10 alkyl,
aryl C0-10 alkyl(carbonyl)0-1oxyC0-10 alkyl,
(C3-8)cycloalkyl C0-10 alkyl(carbonyl)0-1oxyC0-10 alkyl,
heteroarylC0-10 alkyl(carbonyl)0-1oxyC0-10 alkyl,
(C3-8)heterocycloalkyl C0-10 alkyl(carbonyl)0-1oxyC0-10 alkyl,
((C0-10)alkyl)1-2aminocarbonyloxy,
aryl(C0-10)alkylaminocarbonyloxy,
(C3-8)cycloalkyl(C0-10)alkylaminocarbonyloxy,
heteroaryl(C0-10)alkylaminocarbonyloxy,
(C3-8)heterocycloalkyl(C0-10)alkylaminocarbonyloxy,
C1-10 alkylamino(oxy)0-1 carbonylC0-10 alkyl,
C3-8 cycloalkyl C0-10 alkylamino(oxy)0-1carbonylC0-10 alkyl,
aryl C0-10 alkylamino(oxy)0-1carbonylC0-10 alkyl,
heteroaryl C0-10 alkylamino(oxy)0-1carbonylC0-10 alkyl,
(C3-8)heterocycloalkyl C0-10 alkylamino(oxy)0-1carbonylC0-10 alkyl,
C1-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
C3-8 cycloalkyl C0-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
aryl C0-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
heteroaryl C0-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
(C3-8)heterocycloalkyl C0-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
—CO2(C0-10 alkyl),
—(C0-10 alkyl)CO2H,
Oxo (═O),
C1-10 alkylsulfonyl,
C1-10 heteroalkylsulfonyl,
(C3-8)cycloalkylsulfonyl,
(C3-8)cycloheteroalkylsulfonyl,
heteroarylsulfonyl,
arylsulfonyl,
aminosulfonyl,
—SO2N(C1-6alkyl)1-2,
—SO2C1-6alkyl,
—SO2CF3,
—SO2CF2H,
C1-10 alkylsulfinyl,
—OSi(C6H15)
amino,
(C0-10 alkyl)1-2 amino,
—(oxy)0-1(carbonyl)0-1N(C0-10 alkyl)1-2
C1-4 acylamino C0-10 alkyl,
hydroxy,
C1-10 alkoxy,
cyano, and
C1-6 haloalkyl;
and
R6 is optionally substituted with 0, 1, 2, or 3 substituents independently chosen from hydroxy, (C1-6)alkoxy, halogen, CO2H, —(C0-6)alkylCN, —O(C═O)C1-C6 alkyl, NO2, trifluoromethoxy, trifluoroethoxy, —N—C(O)O(C0-6)alkyl, C1-10 alkylsulfonyl, C1-10 heteroalkylsulfonyl, oxo (O═), (C3-8)cycloalkylsulfonyl, (C3-8)cycloheteroalkylsulfonyl, heteroarylsulfonyl, arylsulfonyl, aminosulfonyl, —SO2N(C1-6 alkyl)1-2, —SO2C1-6 alkyl, —SO2CF3, —SO2CF2H, —C1-10 alkylsulfinyl, —O—Si, —OSi(C6H15), —O(0-1)(C1-10)haloalkyl, and NH2.

133 more elements

A compound selected from:

tert-Butyl-4-[4-(aminocarbonyl)-3-anilino-1H-pyrazol-1-yl]-3-cyanopiperidine-1-carboxylate,
tert-Butyl(3R,4S)-4-[4-(aminocarbonyl)-3-anilino-1H-pyrazol-1-yl]-3-cyanopiperidine-1-carboxylate,
tert-Butyl(3S,4R)-4-[4-(aminocarbonyl)-3-anilino-1H-pyrazol-1-yl]-3-cyanopiperidine-1-carboxylate,
tert-butyl(3S,4S)-4-[4-(aminocarbonyl)-3-anilino-1H-pyrazol-1-yl]-3-cyanopiperidine-1-carboxylate,
tert-butyl(3R,4R)-4-[4-(aminocarbonyl)-3-anilino-1H-pyrazol-1-yl]-3-cyanopiperidine-1-carboxylate,
tert-butyl-3-[4-(aminocarbonyl)-3-anilino-1H-pyrazol-1-yl]-4-cyanopiperidine-1-carboxylate,
tert-butyl(3R,4S)-3-[4-(aminocarbonyl)-3-anilino-1H-pyrazol-1-yl]-4-cyanopiperidine-1-carboxylate,
tert-butyl(3S,4R)-3-[4-(aminocarbonyl)-3-anilino-1H-pyrazol-1-yl]-4-cyanopiperidine-1-carboxylate,
tert-butyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
tert-butyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
tert-butyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
tert-butyl 4-(4-carbamoyl-3-((4-fluorophenyl)amino)-1H-pyrazol-1-yl)-3-cyanopiperidine-1-carboxylate,
(3R,4S)-tert-butyl 4-(4-carbamoyl-3-((4-fluorophenyl)amino)-1H-pyrazol-1-yl)-3-cyanopiperidine-1-carboxylate,
(3S,4R)-tert-butyl 4-(4-carbamoyl-3-((4-fluorophenyl)amino)-1H-pyrazol-1-yl)-3-cyanopiperidine-1-carboxylate,
1-4-cyanopiperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanopiperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanopiperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-3-cyanopiperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4R)-3-cyanopiperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4S)-3-cyanopiperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
3,3-Dimethylbutyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
3,3-Dimethylbutyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
3,3-Dimethylbutyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2,2,2-Trifluoro-1-methylethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2,2-Trifluoro-1-methylethyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2,2-Trifluoro-1-methylethyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-fluoroethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-fluoroethyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-fluoroethyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
3-phenylpropyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
3-phenylpropyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
3-phenylpropyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-morpholin-4-ylethyl(3R,4R and 3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-morpholin-4-ylethyl(3R,4R and 3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-morpholin-4-ylethyl(3R,4R and 3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
oxetan-3-yl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
oxetan-3-yl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
oxetan-3-yl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-cyano-2-methylpropyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-cyano-2-methylpropyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-cyano-2-methylpropyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
(1-methylpiperidin-4-yl)methyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
(1-methylpiperidin-4-yl)methyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
(1-methylpiperidin-4-yl)methyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
(1-aminocyclopropyl)methyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
(1-aminocyclopropyl)methyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
(1-aminocyclopropyl)methyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
(1-methylcyclopropyl)methyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
(1-methylcyclopropyl)methyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
(1-methylcyclopropyl)methyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-methylpropyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-methylpropyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-methylpropyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
cyclopentyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
cyclopentyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
cyclopentyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
benzyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
benzyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
benzyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
tetrahydro-2H-pyran-4-yl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
tetrahydro-2H-pyran-4-yl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
tetrahydro-2H-pyran-4-yl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-cyclopropylethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-cyclopropylethyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-cyclopropylethyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-(2-oxopyrrolidin-1-yl)ethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-(2-oxopyrrolidin-1-yl)ethyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-(2-oxopyrrolidin-1-yl)ethyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2-difluoroethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2-difluoroethyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2-difluoroethyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
cyclohexyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
cyclohexyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
cyclohexyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2-dimethylpropyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2-dimethylpropyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2-dimethylpropyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-pyrrolidin-1-ylethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-pyrrolidin-1-ylethyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-pyrrolidin-1-ylethyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2-difluoro-3-hydroxypropyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2-difluoro-3-hydroxypropyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2-difluoro-3-hydroxypropyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
3-(dimethylamino)-2,2-dimethylpropyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate;
3-(dimethylamino)-2,2-dimethylpropyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
3-(dimethylamino)-2,2-dimethylpropyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-(dimethylamino)ethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-(dimethylamino)ethyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-(dimethylamino)ethyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
ethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
ethyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
ethyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-(4-methylpiperazin-1-yl)ethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-(4-methylpiperazin-1-yl)ethyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-(4-methylpiperazin-1-yl)ethyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
tetrahydrofuran-3-yl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
tetrahydrofuran-3-yl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
tetrahydrofuran-3-yl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
1-methylpiperidin-4-yl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
1-methylpiperidin-4-yl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
1-methylpiperidin-4-yl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-methyl-2-(1H-pyrazol-1-yl)propyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-methyl-2-(1H-pyrazol-1-yl)propyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-methyl-2-(1H-pyrazol-1-yl)propyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2,2-trifluoroethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2,2-trifluoroethyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2,2-trifluoroethyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-methoxyethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-methoxyethyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-methoxyethyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
cyclopropylmethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
cyclopropylmethyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
cyclopropylmethyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-fluoro-1-(fluoromethyl)ethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-fluoro-1-(fluoromethyl)ethyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate
2-fluoro-1-(fluoromethyl)ethyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
3-methoxypropyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
3-methoxypropyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
3-methoxypropyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
(3-methyloxetan-3-yl)methyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
(3-methyloxetan-3-yl)methyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
(3-methyloxetan-3-yl)methyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
but-3-yn-1-yl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
but-3-yn-1-yl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
but-3-yn-1-yl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
1-cyclopropylethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
1-cyclopropylethyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
1-cyclopropylethyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-phenylethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-phenylethyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-phenylethyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,3-dihydro-1H-inden-2-yl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,3-dihydro-1H-inden-2-yl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,3-dihydro-1H-inden-2-yl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-ethoxy-2-oxoethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-ethoxy-2-oxoethyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-ethoxy-2-oxoethyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
[1-(cyanomethyl)cyclopropyl]methyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
[1-(cyanomethyl)cyclopropyl]methyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
[1-(cyanomethyl)cyclopropyl]methyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
but-3-yn-1-yl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
but-3-yn-1-yl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
but-3-yn-1-yl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-cyclopropylethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-cyclopropylethyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-cyclopropylethyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,3-dihydro-1H-inden-2-yl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,3-dihydro-1H-inden-2-yl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,3-dihydro-1H-inden-2-yl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2,2-trifluoro-1-methylethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2,2-trifluoro-1-methylethyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2,2-trifluoro-1-methylethyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
ethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
ethyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
ethyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
(3-methyloxetan-3-yl)methyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
(3-methyloxetan-3-yl)methyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
(3-methyloxetan-3-yl)methyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
cyclopropylmethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
cyclopropylmethyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
cyclopropylmethyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-fluoro-1-(fluoromethyl)ethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-fluoro-1-(fluoromethyl)ethyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-fluoro-1-(fluoromethyl)ethyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-phenylethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-phenylethyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-phenylethyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
cyclopentyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
cyclopentyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
cyclopentyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2-dimethylpropyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2-dimethylpropyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2-dimethylpropyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
tetrahydrofuran-3-yl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
tetrahydrofuran-3-yl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
tetrahydrofuran-3-yl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
benzyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
benzyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
benzyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-methyl-2-(1H-pyrazol-1-yl)propyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-methyl-2-(1H-pyrazol-1-yl)propyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-methyl-2-(1H-pyrazol-1-yl)propyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-methoxyethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-methoxyethyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-methoxyethyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
3-phenylpropyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
3-phenylpropyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
3-phenylpropyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-methylpropyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-methylpropyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-methylpropyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
oxetan-3-yl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
oxetan-3-yl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
oxetan-3-yl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-fluoroethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-fluoroethyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-fluoroethyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-ethoxy-2-oxoethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-ethoxy-2-oxoethyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-ethoxy-2-oxoethyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
tetrahydro-2H-pyran-4-yl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
tetrahydro-2H-pyran-4-yl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
tetrahydro-2H-pyran-4-yl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
cyclohexyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
cyclohexyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
cyclohexyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
(1-methylcyclopropyl)methyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
(1-methylcyclopropyl)methyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
(1-methylcyclopropyl)methyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
3-methoxypropyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
3-methoxypropyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
3-methoxypropyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
[1-(cyanomethyl)cyclopropyl]methyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
[1-(cyanomethyl)cyclopropyl]methyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
[1-(cyanomethyl)cyclopropyl]methyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2-difluoroethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2-difluoroethyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2-difluoroethyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2,2-trifluoroethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2,2-trifluoroethyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2,2-trifluoroethyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2-difluoro-3-hydroxypropyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2-difluoro-3-hydroxypropyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2-difluoro-3-hydroxypropyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
1-cyclopropylethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
1-cyclopropylethyl(3R,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
1-cyclopropylethyl(3S,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2-Cyano-2-methylpropyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-Cyano-2-methylpropyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-Cyano-2-methylpropyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2,2,2-trifluoro-1-methylethyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2,2,2-trifluoro-1-methylethyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2,2,2-trifluoro-1-methylethyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-fluoro-1-(fluoromethyl)ethyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-fluoro-1-(fluoromethyl)ethyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-fluoro-1-(fluoromethyl)ethyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
(1-methylcyclopropyl)methyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
(1-methylcyclopropyl)methyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
(1-methylcyclopropyl)methyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
1-cyclopropylethyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
1-cyclopropylethyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
1-cyclopropylethyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2,2-difluoro-3-hydroxypropyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2,2-difluoro-3-hydroxypropyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2,2-difluoro-3-hydroxypropyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
3-(dimethylamino)-2,2-dimethylpropyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
3-(dimethylamino)-2,2-dimethylpropyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
3-(dimethylamino)-2,2-dimethylpropyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
ethyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
ethyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
ethyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-methylpropyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-methylpropyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-methylpropyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2,2,2-trifluoroethyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2,2,2-trifluoroethyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2,2,2-trifluoroethyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-fluoroethyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-fluoroethyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-fluoroethyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2,2-dimethylpropyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2,2-dimethylpropyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2,2-dimethylpropyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
cyclopropylmethyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
cyclopropylmethyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
cyclopropylmethyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
benzyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
benzyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
benzyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-methoxyethyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-methoxyethyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-methoxyethyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-ethoxy-2-oxoethyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-ethoxy-2-oxo ethyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-ethoxy-2-oxo ethyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
tetrahydro-2H-pyran-4-yl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
tetrahydro-2H-pyran-4-yl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
tetrahydro-2H-pyran-4-yl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-(dimethylamino)ethyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-(dimethylamino)ethyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-(dimethylamino)ethyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-morpholin-4-ylethyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-morpholin-4-ylethyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-morpholin-4-ylethyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
[1-(cyanomethyl)cyclopropyl]methyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
[1-(cyanomethyl)cyclopropyl]methyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
[1-(cyanomethyl)cyclopropyl]methyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
oxetan-3-yl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
oxetan-3-yl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
oxetan-3-yl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
(3-methyloxetan-3-yl)methyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
(3-methyloxetan-3-yl)methyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
(3-methyloxetan-3-yl)methyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-cyclopropylethyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-cyclopropylethyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-cyclopropylethyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-methyl-2-(1H-pyrazol-1-yl)propyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-methyl-2-(1H-pyrazol-1-yl)propyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-methyl-2-(1H-pyrazol-1-yl)propyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-methyl-2-(1H-pyrazol-1-yl)propyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-methyl-2-(1H-pyrazol-1-yl)propyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2-methyl-2-(1H-pyrazol-1-yl)propyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2,2-difluoro-3-hydroxypropyl-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2,2-difluoro-3-hydroxypropyl(3S,4R)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2,2-difluoro-3-hydroxypropyl(3R,4S)-3-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-cyanopiperidine-1-carboxylate,
2,2,2-trifluoro-1-methylethyl-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2,2-trifluoro-1-methylethyl(3R,4R)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
2,2,2-trifluoro-1-methylethyl(3S,4S)-4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-3-cyanopiperidine-1-carboxylate,
1-[4-cyano-1-(pyridazin-3-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyano-1-(pyridazin-3-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyano-1-(pyridazin-3-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[4-cyano-1-(pyrazin-2-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyano-1-(pyrazin-2-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyano-1-(pyrazin-2-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[4-cyano-1-(isoxazol-3-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyano-1-(isoxazol-3-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyano-1-(isoxazol-3-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[4-cyano-1-(1,3-oxazol-4-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyano-1-(1,3-oxazol-4-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyano-1-(1,3-oxazol-4-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{4-cyano-1-[(1-methyl-1H-pyrazol-3-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4R)-4-cyano-1-[(1-methyl-1H-pyrazol-3-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4S)-4-cyano-1-[(1-methyl-1H-pyrazol-3-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[4-cyano-1-(1,3-thiazol-4-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyano-1-(1,3-thiazol-4-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyano-1-(1,3-thiazol-4-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{4-cyano-1-[(4-fluoropyridin-2-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4R)-4-cyano-1-[(4-fluoropyridin-2-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4S)-4-cyano-1-[(4-fluoropyridin-2-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[4-cyano-1-(1,3-oxazol-2-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyano-1-(1,3-oxazol-2-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyano-1-(1,3-oxazol-2-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{4-cyano-1-[(3-methoxycyclobutyl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4R)-4-cyano-1-[(3-methoxycyclobutyl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4S)-4-cyano-1-[(3-methoxycyclobutyl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{4-cyano-1-[2-(tetrahydro-2H-pyran-4-yl)ethyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4R)-4-cyano-1-[2-(tetrahydro-2H-pyran-4-yl)ethyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4S)-4-cyano-1-[2-(tetrahydro-2H-pyran-4-yl)ethyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[4-cyano-1-{[3-(1-hydroxy-1-methylethyl)cyclobutyl]methyl}piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyano-1-{[3-(1-hydroxy-1-methylethyl)cyclobutyl]methyl}piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyano-1-{[3-(1-hydroxy-1-methylethyl)cyclobutyl]methyl}piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[4-cyano-1-(cyclobutylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyano-1-(cyclobutylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyano-1-(cyclobutylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(4-cyano-1-[(1-methyl-1H-pyrazol-5-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4R)-4-cyano-1-[(1-methyl-1H-pyrazol-5-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4S)-4-cyano-1-[(1-methyl-1H-pyrazol-5-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(4-cyano-1-[(5-methylisoxazol-3-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4R)-4-cyano-1-[(5-methylisoxazol-3-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4S)-4-cyano-1-[(5-methylisoxazol-3-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{4-cyano-1-[(1,5-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4R)-4-cyano-1-[(1,5-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4S)-4-cyano-1-[(1,5-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{4-cyano-1-[(5-fluoropyridin-2-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4R)-4-cyano-1-[(5-fluoropyridin-2-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4S)-4-cyano-1-[(5-fluoropyridin-2-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{4-cyano-1-[(2-fluoropyridin-3-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4R)-4-cyano-1-[(2-fluoropyridin-3-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4S)-4-cyano-1-[(2-fluoropyridin-3-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4R and 3R,4S)-4-cyano-1-[(2-methyl-1,3-thiazol-5-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4R and 3R,4S)-4-cyano-1-[(2-methyl-1,3-thiazol-5-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4R and 3R,4S)-4-cyano-1-[(2-methyl-1,3-thiazol-5-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{4-cyano-1-[(1-ethyl-1H-imidazol-2-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4R)-4-cyano-1-[(1-ethyl-1H-imidazol-2-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4S)-4-cyano-1-[(1-ethyl-1H-imidazol-2-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{4-cyano-1-[(3-methyl-4,5-dihydroisoxazol-5-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4R)-4-cyano-1-[(3-methyl-4,5-dihydroisoxazol-5-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4S)-4-cyano-1-[(3-methyl-4,5-dihydroisoxazol-5-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[4-cyano-1-(tetrahydrofuran-3-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyano-1-(tetrahydrofuran-3-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyano-1-(tetrahydrofuran-3-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[3-cyano-1-(pyridazin-3-ylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4R)-3-cyano-1-(pyridazin-3-ylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4S)-3-cyano-1-(pyridazin-3-ylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[3-cyano-1-(pyrazin-2-ylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4R)-3-cyano-1-(pyrazin-2-ylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4S)-3-cyano-1-(pyrazin-2-ylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3-cyano-1-(isoxazol-3-ylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4R)-3-cyano-1-(isoxazol-3-ylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4S)-3-cyano-1-(isoxazol-3-ylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[3-cyano-1-(1,3-oxazol-4-ylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4R)-3-cyano-1-(1,3-oxazol-4-ylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4S)-3-cyano-1-(1,3-oxazol-4-ylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{3-cyano-1-[(1-methyl-1H-pyrazol-3-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4R)-3-cyano-1-[(1-methyl-1H-pyrazol-3-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4S)-3-cyano-1-[(1-methyl-1H-pyrazol-3-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[3-cyano-1-(1,3-thiazol-4-ylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4R)-3-cyano-1-(1,3-thiazol-4-ylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4S)-3-cyano-1-(1,3-thiazol-4-ylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{3-cyano-1-[(5-fluoropyridin-3-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4R)-3-cyano-1-[(5-fluoropyridin-3-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4S)-3-cyano-1-[(5-fluoropyridin-3-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[3-cyano-1-(1,3-oxazol-2-ylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4R)-3-cyano-1-(1,3-oxazol-2-ylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4S)-3-cyano-1-(1,3-oxazol-2-ylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{3-cyano-1-[(3-methoxycyclobutyl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4R)-3-cyano-1-[(3-methoxycyclobutyl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4S)-3-cyano-1-[(3-methoxycyclobutyl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{3-cyano-1-[2-(tetrahydro-2H-pyran-4-yl)ethyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4R)-3-cyano-1-[2-(tetrahydro-2H-pyran-4-yl)ethyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4S)-3-cyano-1-[2-(tetrahydro-2H-pyran-4-yl)ethyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{3-cyano-1-[(1-methyl-1H-pyrazol-5-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4R)-3-cyano-1-[(1-methyl-1H-pyrazol-5-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4S)-3-cyano-1-[(1-methyl-1H-pyrazol-5-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{3-cyano-1-[(5-methylisoxazol-3-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4R)-3-cyano-1-[(5-methylisoxazol-3-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4S)-3-cyano-1-[(5-methylisoxazol-3-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{3-cyano-1-[(1,5-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4R)-3-cyano-1-[(1,5-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4S)-3-cyano-1-[(1,5-dimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{3-cyano-1-[(2-fluoropyridin-3-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4R)-3-cyano-1-[(2-fluoropyridin-3-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4S)-3-cyano-1-[(2-fluoropyridin-3-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{3-cyano-1-[(6-fluoropyridin-2-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4S)-3-cyano-1-[(6-fluoropyridin-2-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4R)-3-cyano-1-[(6-fluoropyridin-2-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{3-cyano-1-[(2-methyl-1,3-thiazol-5-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4R)-3-cyano-1-[(2-methyl-1,3-thiazol-5-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4S)-3-cyano-1-[(2-methyl-1,3-thiazol-5-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{3-cyano-1-[(1-ethyl-1H-imidazol-2-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4R)-3-cyano-1-[(1-ethyl-1H-imidazol-2-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4S)-3-cyano-1-[(1-ethyl-1H-imidazol-2-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{3-cyano-1-[(3-methyl-4,5-dihydroisoxazol-5-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3R,4R)-3-cyano-1-[(3-methyl-4,5-dihydroisoxazol-5-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4S)-3-cyano-1-[(3-methyl-4,5-dihydroisoxazol-5-yl)methyl]piperidin-4-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[3-cyano-1-(cyclobutylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4R)-3-cyano-1-(cyclobutylmethyl)piperidin-4-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[4-cyano-1-(1,3-thiazol-5-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyano-1-(1,3-thiazol-5-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyano-1-(1,3-thiazol-5-ylmethyl)piperidin-3-yl]-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{4-cyano-1-[(4-methyl-1,3-oxazol-5-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4R)-4-cyano-1-[(4-methyl-1,3-oxazol-5-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-{(3S,4R,3R,4S)-4-cyano-1-[(4-methyl-1,3-oxazol-5-yl)methyl]piperidin-3-yl}-3-[(4-fluorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-(3-cyano-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-(4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3R,4S)-3-cyano-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-((4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3S,4R)-3-cyano-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-((4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-(3-cyano-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-(4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3R,4S)-3-cyano-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-((4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3S,4R)-3-cyano-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-((4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-(3-cyano-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-((4-(trifluoromethyl)phenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3R,4R)-3-cyano-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-((4-(trifluoromethyl)phenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3S,4S)-3-cyano-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-((4-(trifluoromethyl)phenyl)amino)-1H-pyrazole-4-carboxamide,
1-(3-cyano-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-((4-(trifluoromethyl)phenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3R,4S)-3-cyano-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-((4-(trifluoromethyl)phenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3S,4R)-3-cyano-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-((4-(trifluoromethyl)phenyl)amino)-1H-pyrazole-4-carboxamide,
1-(4-cyano-1,1-dioxidotetrahydrothiophen-3-yl)-3-(4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3S,4S)-4-cyano-1,1-dioxidotetrahydrothiophen-3-yl)-3-((4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3R,4R)-4-cyano-1,1-dioxidotetrahydrothiophen-3-yl)-3-(4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-(4-cyano-1,1-dioxidotetrahydrothiophen-3-yl)-3-(4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3S,4R)-4-cyano-1,1-dioxidotetrahydrothiophen-3-yl)-3-((4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3R,4S)-4-cyano-1,1-dioxidotetrahydrothiophen-3-yl)-3-((4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-(4-cyano-1,1-dioxidotetrahydrothiophen-3-yl)-3-((4-((trifluoromethyl)sulfonyl)phenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3S,4R)-4-cyano-1,1-dioxidotetrahydrothiophen-3-yl)-3-((4-((trifluoromethyl)sulfonyl)phenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3R,4S)-4-cyano-1,1-dioxidotetrahydrothiophen-3-yl)-3-((4-((trifluoromethyl)sulfonyl)phenyl)amino)-1H-pyrazole-4-carboxamide,
1-(4-cyano-1,1-dioxidotetrahydrothiophen-3-yl)-3-((2-fluoropyridin-4-yl)amino)-1H-pyrazole-4-carboxamide,
1-((3S,4S)-4-cyano-1,1-dioxidotetrahydrothiophen-3-yl)-3-((2-fluoropyridin-4-yl)amino)-1H-pyrazole-4-carboxamide,
1-((3R,4R)-4-cyano-1,1-dioxidotetrahydrothiophen-3-yl)-3-((2-fluoropyridin-4-yl)amino)-1H-pyrazole-4-carboxamide,
1-(4-cyano-4-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-3-((4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3S,4R)-4-cyano-4-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-3-((4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3R,4S)-4-cyano-4-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-3-((4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-(4-cyano-4-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-3-((4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3S,4S)-4-cyano-4-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-3-((4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3R,4R)-4-cyano-4-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-3-(4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-(4-cyano-tetrahydro-2H-pyran-3-yl)-3-(2-fluoropyridin-4-ylamino)-1H-pyrazole-4-carboxamide,
1-((3R,4S-4-cyano-tetrahydro-2H-pyran-3-yl)-3-(2-fluoropyridin-4-ylamino)-1H-pyrazole-4-carboxamide,
1-((3S,4R)-4-cyano-tetrahydro-2H-pyran-3-yl)-3-(2-fluoropyridin-4-ylamino)-1H-pyrazole-4-carboxamide,
1-(4-cyano-tetrahydro-2H-pyran-3-yl)-3-(2-fluoropyridin-4-ylamino)-1H-pyrazole-4-carboxamide,
1-((3S,4R)-4-cyano-tetrahydro-2H-pyran-3-yl)-3-(2-fluoropyridin-4-ylamino)-1H-pyrazole-4-carboxamide,
1-((3R,4S)-4-cyano-tetrahydro-2H-pyran-3-yl)-3-(2-fluoropyridin-4-ylamino)-1H-pyrazole-4-carboxamide,
1-(4-cyano-tetrahydro-2H-pyran-3-yl)-3-(2-fluoropyridin-4-ylamino)-1H-pyrazole-4-carboxamide,
1-((3R,4S)-4-cyano-tetrahydro-2H-pyran-3-yl)-3-(2-fluoropyridin-4-ylamino)-1H-pyrazole-4-carboxamide,
1-((3S,4R)-4-cyano-tetrahydro-2H-pyran-3-yl)-3-(2-fluoropyridin-4-ylamino)-1H-pyrazole-4-carboxamide,
1-(4-cyanotetrahydro-2H-pyran-3-yl)-3-((4-(trifluoromethoxy)phenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-3-((4-(trifluoromethoxy)phenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl)-3-((4-(trifluoromethoxy)phenyl)amino)-1H-pyrazole-4-carboxamide,
3-[(4-chlorophenyl)amino]-1-[4-cyanotetrahydro-2H-pyran-3-yl]-1H-pyrazole-4-carboxamide,
3-[(4-chlorophenyl)amino]-1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-1H-pyrazole-4-carboxamide,
3-[(4-chlorophenyl)amino]-1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-1H-pyrazole-4-carboxamide,
1-[4-cyanotetrahydro-2H-pyran-3-yl]-3-[(2-fluoropyridin-4-yl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-[(2-fluoropyridin-4-yl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-[(2-fluoropyridin-4-yl)amino]-1H-pyrazole-4-carboxamide,
1-[4-cyanotetrahydro-2H-pyran-3-yl]-3-({4-[(1R or 1S)-2,2,2-trifluoro-1-hydroxyethyl]phenyl}amino)-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-({4-[(1R or 1S)-2,2,2-trifluoro-1-hydroxyethyl]phenyl}amino)-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-({4-[(1R or 1S)-2,2,2-trifluoro-1-hydroxyethyl]phenyl}amino)-1H-pyrazole-4-carboxamide,
1-[4-cyanotetrahydro-2H-pyran-3-yl]-3-({4-[2,2,2-trifluoro-1-hydroxyethyl]phenyl}amino)-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-({4-[(1S)-2,2,2-trifluoro-1-hydroxyethyl]phenyl}amino)-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-({4-[(1S)-2,2,2-trifluoro-1-hydroxyethyl]phenyl}amino)-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-({4-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]phenyl}amino)-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-({4-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]phenyl}amino)-1H-pyrazole-4-carboxamide,
1-[(4-cyanotetrahydro-2H-pyran-3-yl]-3-[(3,4-dichlorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-[(3,4-dichlorophenyl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-[(3,4-dichlorophenyl)amino]-1H-pyrazole-4-carboxamide,
3-[(4-chloro-3-fluorophenyl)amino]-1-[(4-cyanotetrahydro-2H-pyran-3-yl]-1H-pyrazole-4-carboxamide,
3-[(4-chloro-3-fluorophenyl)amino]-1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-1H-pyrazole-4-carboxamide,
3-[(4-chloro-3-fluorophenyl)amino]-1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-1H-pyrazole-4-carboxamide,
1-[4-cyanotetrahydro-2H-pyran-3-yl]-3-{[6-(trifluoromethyl)pyridin-3-yl]amino}-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[6-(trifluoromethyl)pyridin-3-yl]amino}-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[6-(trifluoromethyl)pyridin-3-yl]amino}-1H-pyrazole-4-carboxamide,
1-[4-cyanotetrahydro-2H-pyran-3-yl]-3-({4-[2,2-difluoro-1-hydroxy-1-methylethyl]phenyl}amino)-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-({4-[(1R)-2,2-difluoro-1-hydroxy-1-methylethyl]phenyl}amino)-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-({4-[(1S)-2,2-difluoro-1-hydroxy-1-methylethyl]phenyl}amino)-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-({4-[(1R)-2,2-difluoro-1-hydroxy-1-methylethyl]phenyl}amino)-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-({4-[(1S)-2,2-difluoro-1-hydroxy-1-methylethyl]phenyl}amino)-1H-pyrazole-4-carboxamide,
1-[(4-cyanotetrahydro-2H-pyran-3-yl]-3-{[4-(trifluoromethoxy)phenyl]amino}-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[4-(trifluoromethoxy)phenyl]amino}-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[4-(trifluoromethoxy)phenyl]amino}-1H-pyrazole-4-carboxamide,
3-[(7-chloroquinolin-3-yl)amino]-1-[4-cyanotetrahydro-2H-pyran-3-yl]-1H-pyrazole-4-carboxamide,
3-[(7-chloroquinolin-3-yl)amino]-1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-1H-pyrazole-4-carboxamide,
3-[(7-chloroquinolin-3-yl)amino]-1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-1H-pyrazole-4-carboxamide,
1-[4-cyanotetrahydro-2H-pyran-3-yl]-3-{[4-(trifluoromethoxy)phenyl]amino}-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[4-(trifluoromethoxy)phenyl]amino}-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[4-(trifluoromethoxy)phenyl]amino}-1H-pyrazole-4-carboxamide,
3-[(4-chloro-3-fluorophenyl)amino]-1-[4-cyanotetrahydro-2H-pyran-3-yl]-1H-pyrazole-4-carboxamide,
3-[(4-chloro-3-fluorophenyl)amino]-1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-1H-pyrazole-4-carboxamide,
3-[(4-chloro-3-fluorophenyl)amino]-1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-1H-pyrazole-4-carboxamide,
1-[(4-cyanotetrahydro-2H-pyran-3-yl]-3-{[4-(1-methoxy-1-methylethyl)phenyl]amino}-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[4-(3-methyloxetan-3-yl)phenyl]amino}-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[4-(3-methyloxetan-3-yl)phenyl]amino}-1H-pyrazole-4-carboxamide,
1-[4-cyanotetrahydro-2H-pyran-3-yl]-3-{[4-(1-methoxy-1-methylethyl)phenyl]amino}-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[4-(3-methyloxetan-3-yl)phenyl]amino}-1H-pyrazole-4-carboxamide,
1-[(3R,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[4-(1-methoxy-1-methylethyl)phenyl]amino}-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[4-(3-methyloxetan-3-yl)phenyl]amino}-1H-pyrazole-4-carboxamide,
3-[(6-chloropyridin-3-yl)amino]-1-[(4-cyanotetrahydro-2H-pyran-3-yl]-1H-pyrazole-4-carboxamide,
3-[(6-chloropyridin-3-yl)amino]-1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-1H-pyrazole-4-carboxamide,
3-[(6-chloropyridin-3-yl)amino]-1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-1H-pyrazole-4-carboxamide,
1-[(4-cyanotetrahydro-2H-pyran-3-yl]-3-{[6-(trifluoromethyl)pyridin-3-yl]amino}-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[6-(trifluoromethyl)pyridin-3-yl]amino}-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[6-(trifluoromethyl)pyridin-3-yl]amino}-1H-pyrazole-4-carboxamide,
1-[(4-cyanotetrahydro-2H-pyran-3-yl]-3-[(6-fluoropyridin-3-yl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-[(6-fluoropyridin-3-yl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-[(6-fluoropyridin-3-yl)amino]-1H-pyrazole-4-carboxamide,
1-[(4-cyanotetrahydro-2H-pyran-3-yl]-3-[(5-fluoropyridin-3-yl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-[(5-fluoropyridin-3-yl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-[(5-fluoropyridin-3-yl)amino]-1H-pyrazole-4-carboxamide,
1-[4-cyanotetrahydro-2H-pyran-3-yl]-3-{[6-(difluoromethyl)pyridin-3-yl]amino}-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[6-(difluoromethyl)pyridin-3-yl]amino}-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[6-(difluoromethyl)pyridin-3-yl]amino}-1H-pyrazole-4-carboxamide,
1-[4-cyanotetrahydro-2H-pyran-3-yl]-3-{[4-(dimethylcarbamoyl)phenyl]amino}-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[4-(dimethylcarbamoyl)phenyl]amino}-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[4-(dimethylcarbamoyl)phenyl]amino}-1H-pyrazole-4-carboxamide,
3-[(4-cyanophenyl)amino]-1-[4-cyanotetrahydro-2H-pyran-3-yl]-1H-pyrazole-4-carboxamide,
3-[(4-cyanophenyl)amino]-1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-1H-pyrazole-4-carboxamide,
3-[(4-cyanophenyl)amino]-1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-1H-pyrazole-4-carboxamide,
1-[4-cyanotetrahydro-2H-pyran-3-yl]-3-{[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]amino}-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]amino}-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]amino}-1H-pyrazole-4-carboxamide,
1-[4-cyanotetrahydro-2H-pyran-3-yl]-3-(phenylamino)-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-(phenylamino)-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-(phenylamino)-1H-pyrazole-4-carboxamide,
1-[4-cyanotetrahydro-2H-pyran-3-yl]-3-[(2-fluoropyridin-4-yl)amino]-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-[(2-fluoropyridin-4-yl)amino]-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-[(2-fluoropyridin-4-yl)amino]-1H-pyrazole-4-carboxamide,
1-[4-cyanotetrahydro-2H-pyran-3-yl]-3-{[6-(trifluoromethyl)pyridin-3-yl]amino}-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[6-(trifluoromethyl)pyridin-3-yl]amino}-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-{[6-(trifluoromethyl)pyridin-3-yl]amino}-1H-pyrazole-4-carboxamide,
1-[4-cyanotetrahydro-2H-pyran-3-yl]-3-({4-[2,2-difluoro-1-hydroxy-1-methylethyl]phenyl}amino)-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-({4-[(1R)-2,2-difluoro-1-hydroxy-1-methylethyl]phenyl}amino)-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-({4-[(1R)-2,2-difluoro-1-hydroxy-1-methylethyl]phenyl}amino)-1H-pyrazole-4-carboxamide,
1-[(3S,4R)-4-cyanotetrahydro-2H-pyran-3-yl]-3-({4-[(1S)-2,2-difluoro-1-hydroxy-1-methylethyl]phenyl}amino)-1H-pyrazole-4-carboxamide,
1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-({4-[(1S)-2,2-difluoro-1-hydroxy-1-methylethyl]phenyl}amino)-1H-pyrazole-4-carboxamide,
1-(4-Cyano-6-methyltetrahydro-2H-pyran-3-yl)-3-((2-fluoropyridin-4-yl)amino)-1H-pyrazole-4-carboxamide,
1-((3R,4S,6R)-4-Cyano-6-methyltetrahydro-2H-pyran-3-yl)-3-((2-fluoropyridin-4-yl)amino)-1H-pyrazole-4-carboxamide,
1-((3R,4R,6R)-4-Cyano-6-methyltetrahydro-2H-pyran-3-yl)-3-((2-fluoropyridin-4-yl)amino)-1H-pyrazole-4-carboxamide,
1-((3R,4R,6S)-4-Cyano-6-methyltetrahydro-2H-pyran-3-yl)-3-((2-fluoropyridin-4-yl)amino)-1H-pyrazole-4-carboxamide,
1-((3R,4S,6S)-4-Cyano-6-methyltetrahydro-2H-pyran-3-yl)-3-((2-fluoropyridin-4-yl)amino)-1H-pyrazole-4-carboxamide,
1-((3S,4S,6R)-4-Cyano-6-methyltetrahydro-2H-pyran-3-yl)-3-((2-fluoropyridin-4-yl)amino)-1H-pyrazole-4-carboxamide,
1-((3S,4S,6S)-4-Cyano-6-methyltetrahydro-2H-pyran-3-yl)-3-((2-fluoropyridin-4-yl)amino)-1H-pyrazole-4-carboxamide,
1-((3S,4R,6R)-4-Cyano-6-methyltetrahydro-2H-pyran-3-yl)-3-((2-fluoropyridin-4-yl)amino)-1H-pyrazole-4-carboxamide,
1-((3S,4R,6S)-4-Cyano-6-methyltetrahydro-2H-pyran-3-yl)-3-((2-fluoropyridin-4-yl)amino)-1H-pyrazole-4-carboxamide,
1-(3-cyano-tetrahydro-2H-pyran-4-yl)-3-(2-fluoropyridin-4-ylamino)-1H-pyrazole-4-carboxamide,
1-((3R,4R)-3-cyano-tetrahydro-2H-pyran-4-yl)-3-(2-fluoropyridin-4-ylamino)-1H-pyrazole-4-carboxamide,
1-((3S,4S)-3-cyano-tetrahydro-2H-pyran-4-yl)-3-(2-fluoropyridin-4-ylamino)-1H-pyrazole-4-carboxamide,
1-(3-cyano-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-(4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3R,4R)-3-cyano-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-((4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3S,4S)-3-cyano-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-(4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3-cyano-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-((4-(trifluoromethyl)phenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3R,4S)-3-cyano-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-((4-(trifluoromethyl)phenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3S,4R)-3-cyano-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-((4-(trifluoromethyl)phenyl)amino)-1H-pyrazole-4-carboxamide,
1-(4-cyano-4-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-3-((4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3S,4R)-4-cyano-4-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-3-((4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3R4S)-4-cyano-4-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-3-((4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-(4-Cyano-4-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-3-((4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3R,4R)-4-Cyano-4-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-3-((4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide,
1-((3S,4S)-4-Cyano-4-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-3-((4-fluorophenyl)amino)-1H-pyrazole-4-carboxamide;
or a pharmaceutically acceptable salt or stereoisomer thereof.

582 more elements

Dependencies are inferred from the claim text.

Facts

Application: 14/345,982Filed 21 Sep 2012
Priority: 22 Sep 2011
Published: 21 Aug 2014
Term ends: Not estimatedThe source records don’t support an estimate.

Classification31 codes

C07D 405/08
Containing two hetero rings: linked by a carbon chain containing alicyclic rings
A61P 11/00
Drugs for disorders of the respiratory system
A61P 11/06
Drugs for disorders of the respiratory system: antiasthmatics
A61P 11/08
Drugs for disorders of the respiratory system: bronchodilators

Family

Application61/537,978Us provisional application · filed 22 Sep 2011
US 9,394,282 B2Related patent
US 2014/0235641 A1This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

A compound of formula I or a pharmaceutically acceptable salt or stereoisomer thereof:

Ra and R4 are each independently chosen from hydrogen and C1-4alkyl;
n is 0, 1, 2, 3, or 4;
p is 2, 3, or 4;
X is independently chosen from C, N, S, and O, wherein at least one X is other than carbon;
A is chosen from aryl, and heteroaryl;
R2 and R3 are each independently selected from:
hydrogen,
halogen,
C1-10 alkyl,
C2-10 alkenyl,
C1-10 heteroalkyl,
aryl C0-10 alkylC0-10 alkyl,
C3-8 cycloalkylC0-10 alkyl,
heteroaryl C0-10 alkyl,
(C3-8)heterocycloalkyl C0-10 alkyl,
wherein each of R2 and R3 are independently substituted with 0, 1, 2, 3, or 4, substituents R5a;
R5a is selected from:
hydrogen,
halogen,
C1-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
C1-10 heteroalkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
C2-10 alkenyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
aryl C0-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
aryl C2-10 alkenyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
aryl C2-10 alkynyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
C3-8 cycloalkyl C0-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
heteroaryl C0-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
(C3-8)heterocycloalkyl C0-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
C1-10 alkyl(carbonyl)0-1oxyC0-10 alkyl,
C1-10 heteroalkyl(carbonyl)0-1oxyC0-10 alkyl,
C2-10 alkenyl(carbonyl)0-1oxyC0-10 alkyl,
C1-10 heteroalkyl(carbonyl)0-1oxyC0-10 alkyl,
aryl C0-10 alkyl(carbonyl)0-1oxyC0-10alkyl,
(C3-8)cycloalkyl C0-10 alkyl(carbonyl)0-1oxyC0-10 alkyl,
heteroarylC0-10 alkyl(carbonyl)0-1oxyC0-10 alkyl,
(C3-8)heterocycloalkyl C0-10 alkyl(carbonyl)0-1oxyC0-10 alkyl,
((C0-10)alkyl)1-2aminocarbonyloxy,
(C0-10)heteroalkylaminocarbonyloxy,
aryl(C0-10)alkylaminocarbonyloxy,
(C3-8)cycloalkyl(C0-10)alkylaminocarbonyloxy,
heteroaryl(C0-10)alkylaminocarbonyloxy,
(C3-8)heterocycloalkyl(C0-10)alkylaminocarbonyloxy,
C1-10 alkylamino(oxy)0-1carbonylC0-10 alkyl,
(C0-10)heteroalkylamino(oxy)0-1carbonylC0-10 alkyl,
C3-8 cycloalkyl C0-10 alkylamino(oxy)0-1carbonylC0-10 alkyl,
aryl C0-10alkylamino(oxy)0-1carbonylC0-10 alkyl,
heteroarylC0-10alkylamino(oxy)0-1carbonylC0-10 alkyl,
(C3-8)heterocycloalkylC0-10alkylamino(oxy)0-1carbonylC0-10 alkyl,
C1-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
C1-10 heteroalkyl(oxy)0-1carbonylaminoC0-10 alkyl,
C3-8 cycloalkyl C0-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
aryl C0-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
heteroaryl C0-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
(C3-8)heterocycloalkyl C0-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
—CO2(C0-10 alkyl),
—(C0-10 alkyl)CO2H,
Oxo (═O),
C1-10 alkylsulfonyl,
C1-10 heteroalkylsulfonyl,
(C3-8)cycloalkylsulfonyl,
(C3-8)cycloheteroalkylsulfonyl,
heteroarylsulfonyl,
arylsulfonyl,
aminosulfonyl,
—SO2N(C1-6alkyl)1-2,
—SO2C1-6alkyl,
—SO2CF3,
—SO2CF2H,
C1-10 alkylsulfinyl,
amino,
(C0-10 alkyl)1-2 amino,
C1-4 acylamino C0-10 alkyl,
hydroxy,
C0-10 alkylalkoxy,
cyano,
C1-6 alkylcyano, and
C1-6 haloalkyl;
wherein R5a is each optionally substituted with 0, 1, 2, 3, or 4 substituents, R6, independently selected from:
halogen,
C1-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
C1-10 heteroalkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
C2-10 alkenyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
aryl C0-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
aryl C2-10 alkenyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
aryl C2-10 alkynyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
C3-8 cycloalkyl C0-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
heteroaryl C0-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
(C3-8)heterocycloalkyl C0-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,
C1-10 alkyl(carbonyl)0-1oxyC0-10 alkyl,
C2-10 alkenyl(carbonyl)0-1oxyC0-10 alkyl,
C1-10 heteroalkyl(carbonyl)0-1oxyC0-10 alkyl,
aryl C0-10 alkyl(carbonyl)0-1oxyC0-10 alkyl,
(C3-8)cycloalkyl C0-10 alkyl(carbonyl)0-1oxyC0-10 alkyl,
heteroarylC0-10 alkyl(carbonyl)0-1oxyC0-10 alkyl,
(C3-8)heterocycloalkyl C0-10 alkyl(carbonyl)0-1oxyC0-10 alkyl,
((C0-10)alkyl)1-2aminocarbonyloxy,
aryl(C0-10)alkylaminocarbonyloxy,
(C3-8)cycloalkyl(C0-10)alkylaminocarbonyloxy,
heteroaryl(C0-10)alkylaminocarbonyloxy,
(C3-8)heterocycloalkyl(C0-10)alkylaminocarbonyloxy,
C1-10 alkylamino(oxy)0-1 carbonylC0-10 alkyl,
C3-8 cycloalkyl C0-10 alkylamino(oxy)0-1carbonylC0-10 alkyl,
aryl C0-10 alkylamino(oxy)0-1carbonylC0-10 alkyl,
heteroaryl C0-10 alkylamino(oxy)0-1carbonylC0-10 alkyl,
(C3-8)heterocycloalkyl C0-10 alkylamino(oxy)0-1carbonylC0-10 alkyl,
C1-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
C3-8 cycloalkyl C0-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
aryl C0-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
heteroaryl C0-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
(C3-8)heterocycloalkyl C0-10 alkyl(oxy)0-1carbonylaminoC0-10 alkyl,
—CO2(C0-10 alkyl),
—(C0-10 alkyl)CO2H,
Oxo (═O),
C1-10 alkylsulfonyl,
C1-10 heteroalkylsulfonyl,
(C3-8)cycloalkylsulfonyl,
(C3-8)cycloheteroalkylsulfonyl,
heteroarylsulfonyl,
arylsulfonyl,
aminosulfonyl,
—SO2N(C1-6alkyl)1-2,
—SO2C1-6alkyl,
—SO2CF3,
—SO2CF2H,
C1-10 alkylsulfinyl,
—OSi(C6H15)
amino,
(C0-10 alkyl)1-2 amino,
—(oxy)0-1(carbonyl)0-1N(C0-10 alkyl)1-2
C1-4 acylamino C0-10 alkyl,
hydroxy,
C1-10 alkoxy,
cyano, and
C1-6 haloalkyl;
and
R6 is optionally substituted with 0, 1, 2, or 3 substituents independently chosen from hydroxy, (C1-6)alkoxy, halogen, CO2H, —(C0-6)alkylCN, —O(C═O)C1-C6 alkyl, NO2, trifluoromethoxy, trifluoroethoxy, —N—C(O)O(C0-6)alkyl, C1-10 alkylsulfonyl, C1-10 heteroalkylsulfonyl, oxo (O═), (C3-8)cycloalkylsulfonyl, (C3-8)cycloheteroalkylsulfonyl, heteroarylsulfonyl, arylsulfonyl, aminosulfonyl, —SO2N(C1-6 alkyl)1-2, —SO2C1-6 alkyl, —SO2CF3, —SO2CF2H, —C1-10 alkylsulfinyl, —O—Si, —OSi(C6H15), —O(0-1)(C1-10)haloalkyl, and NH2.

133 more elements

Facts

Application

14/345,982Filed 21 Sep 2012

Priority

22 Sep 2011

Published

21 Aug 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification31 codes

C07D 405/08
Containing two hetero rings: linked by a carbon chain containing alicyclic rings
A61P 11/00
Drugs for disorders of the respiratory system
A61P 11/06
Drugs for disorders of the respiratory system: antiasthmatics
A61P 11/08
Drugs for disorders of the respiratory system: bronchodilators