Compounds and methods for treating inflammatory and fibrotic disorders

A compound of formula II:

• or a pharmaceutically acceptable salt, ester, or solvate thereof, wherein
• R1 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkenyl, cyano, sulfonamido, halo, aryl, alkenylenearyl, and heteroaryl;
• R2 is selected from the group consisting of alkyl;
• haloalkyl;
• halo;
• cyano;
• aryl;
• alkenyl;
• alkenylenearyl;
• unsubstituted heteroaryl;
• heteroaryl substituted with one or more substituents selected from halo, unsubstituted alkyl, alkenyl, OCF3, NO2, CN, OH, alkoxy, haloalkoxy, amino, CO2H, and CO2alkyl;
• haloalkylcarbonyl;
• cycloalkyl;
• hydroxyalkyl;
• sulfonamido;
• unsubstituted cycloheteroalkyl and cycloheteroalkyl substituted with one to three substituents independently selected from alkyl, hydroxyalkyl, C(O)NH2, NH2, oxo, aryl, haloalkyl, halo, and hydroxy;
• R3 is selected from the group consisting of hydrogen, aryl, alkenylenearyl, heteroaryl, alkyl, alkenyl, haloalkyl, amino, and hydroxy;
• R4 is selected from the group consisting of hydrogen, alkyl, haloalkyl, cyano, alkoxy, aryl, alkenyl, alkenylenearyl, and heteroaryl;
• X1, X2, X4, and X5 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, halo, hydroxy, amino, aryl, cycloalkyl, thioalkyl, alkoxy, haloalkyl, haloalkoxy, alkoxyalkyl, cyano, aldehydo, alkylcarbonyl, amido, haloalkylcarbonyl, sulfonyl, and sulfonamide;
• and
• X3 is alkoxy substituted with one or more substituents selected from the group consisting of alkyl;
• cycloalkyl optionally substituted with one to three groups independently selected from alkyl, alkyleneOH, C(O)NH2, NH2, oxo (═O), aryl, haloalkyl, halo, and OH;
• aryl optionally substituted with one to four groups independently selected from halo, alkyl, alkenyl, OCF3, NO2, CN, NC, OH, alkoxy, haloalkoxy, amino, CO2H, CO2alkyl, aryl, and heteroaryl;
• heterocycloalkyl optionally substituted with one to three groups independently selected from alkyl, alkyleneOH, C(O)NH2, NH2, oxo (═O), aryl, haloalkyl, halo, and OH;
• heteroaryl optionally substituted with one to four groups independently selected from halo, alkyl, alkenyl, OCF3, NO2, CN, NC, OH, alkoxy, haloalkoxy, amino, CO2H, CO2alkyl, aryl, and heteroaryl;
• hydroxyl;
• alkoxy;
• aryloxy;
• mercapto;
• alkylthio;
• arylthio;
• cyano;
• halo;
• carbonyl;
• thiocarbonyl;
• alkoxycarbonyl;
• nitro;
• silyl;
• trihalomethanesulfonyl;
• trifluoromethyl;
• and amino.