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US 2014/0235616 A1Published application
Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof
AssigneeSanofi
InventorsAlexandre Benazet, Olivier Duclos, Nathalie Guillo, Gilbert Lassalle, Karim Macary, Valerie Vin
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Abstract
The invention relates to compounds corresponding to formula (I), in which R1, R2 and R3 are as defined in Claim 1, and also to the process for preparing them and to their therapeutic use.
Claims25
A compound corresponding to formula (I):
- in which:
- R1 represents:
- —(C1-C4)alkyl
- (C1-C4) haloalkyl
- R2 represents:
- a group:
- a group:
- a group;
- -A—X
- R3 represents:
- —H
- halogen
- —(C1-C6)alkyl
- a cyano group
- —CO2H
- —CONH2
- A represents:
- an aryl or heteroaryl group
- X is absent or represents:
- halogen
- a cyano group
- an oxo group
- —(CH2)nOH
- —(C1-C6)haloalkyl
- —(C1-C6)alkyl
- —(C1-C6)alkoxy
- —(CH2)n-aryl
- —CHOH-aryl
- heterocycle
- heteroaryl
- —(C1-C6)alkyl-heterocycle
- —(C1-C6)alkyl-heteroaryl
- —(C1-C6)alkyl-COORa
- —(C1-C6)alkyl-NRaRb
- -heteroaryl-(CH2)n-NRaRb
- —(CH2)n-NRa-C(O)—Rb
- —NRaRb
- —NRa-(CH2)n-O—Rb
- —NRa-heterocycle
- —NRa-aryl
- —NRa-C(O)—(CH2)n-NRaRb
- —NRa-C(O)-aryl
- —NRaC(O)—(C1-C6)alkyl
- —NRa-C(O)—(C1-C6)alkyl-aryl
- —NRa-C(O)—(CH2)n-O—Rb
- —NRa-SO2-(CH2)n-aryl
- —NRa-SO2-(CH2)n-NRaRb
- —NRa-SO2-Rb
- —NRa-SO2-aryl-O-aryl
- —NRa-SO2-aryl-(CH2)n-NRb-C(O)—Rb
- —COORa
- —CONRaRb
- —C(O)—NRa-(CH2)n-O—Rb
- —C(O)—NRa-aryl-C(O)—NRaRb
- —C(O)—NRa-(CH2)n-NRaRb
- —C(O)—NRa-(CH2)n-heteroaryl
- —O—(CH2)n-NRaRb
- —O-heterocycle
- —CO-heterocycle
- —CO-heteroaryl
- —SO2NRaRb
- —SO2-heterocycle
- Ra and Rb represent, independently:
- —H
- —(C1-C6)alkyl
- n represents 0, 1, 2 or 3
- in the form of the base or of an acid-addition salt, and also in hydrate form.
64 more elements
(canceled)
(canceled)
Dependencies are inferred from the claim text.