Compounds and methods of treating ocular disorders

A method of treating a retinal pathology associated with aberrant all-trans-retinal clearance in the retina outer segment of a subject in need thereof, the method comprising:

• administering to the subject a therapeutically effective amount of a primary amine compound of formula:
• wherein R1 is an aliphatic and/or aromatic compound;
• the primary amine compound upon administration to the subject forming a reversible Schiff-base with the all-trans-retinal without adversely affecting normal retinoid cycle performance;
• the primary amine compound when administered to a Rdh8-/-Abca4-/- mouse increasing the optical coherence tomography score of the mouse to at least about 2.5 and increasing 11-cis-retinal amount at least about 30% in comparison to untreated control animal, wherein the primary amine compound is not a local anesthetic, which includes an aromatic amine, that demonstrates sodium channel blockade when administered to the subject.