Compositions and Methods for Suppressing Endometrial Proliferation

A method for treating chronic estrogen-dependent hyperproliferation of uterine tissue according to an intermittent administration regimen comprising administering to a human female in need of such treatment a therapeutically effective amount of a selective progesterone receptor modulator (SPRM) for an administration period during which the SPRM is administered daily or every other day consecutively over a period of from one to six months, then discontinuing said administration for a discontinuance period by means of a continual lack of treatment for a period of time sufficient for the female to undergo menstruation, said period of time being equal to or less than the number of days during which the SPRM was previously administered, then administering a therapeutically effective amount of an SPRM daily or every other day consecutively over a period of from one to six months, then discontinuing said administration by means of continual lack of treatment for a period of time sufficient for the female to undergo menstruation, said period of time being equal to or less than the number of days during which the compound was previously administered, and repeating this pattern of administration and discontinuance of administration for a sufficient duration to treat the chronic condition.