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US 2014/0235595 A1Published application
Cocrystals of progesterone
AssigneeAptuit, Inc.
InventorsEkaterina ALBERT, Patricia ANDRES, Melanie Janelle BEVILL, Jared SMIT, Jennifer NELSON
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Abstract
Disclosed herein are cocrystals of progesterone and a coformer containing a six-membered aromatic ring having at least one substituent possessing a carbonyl functionality. Cocrystals of progesterone and a coformer selected from vanillic acid, benzoic acid, salicylic acid, cinnamic acid, or vanillin are also disclosed herein.
Claims20
A cocrystal of progesterone and a coformer of the structure of Formula I:
- wherein R1 is H, OH, C(O)H, alkyl-CO2H, or alkenyl-CO2H;
- R2 is H or OH;
- R3 is H, OH, or O-alkyl;
- and R4 is H or OH, provided that at least one of R1, R2, R3, and R4 is not H or OH and that at least one of R1, R2, R3, and R4 contains a carbonyl moiety.
1 more element
A cocrystal of progesterone and a coformer selected from vanillic acid, benzoic acid, salicylic acid, vanillin, or cinnamic acid.
Dependencies are inferred from the claim text.