Pharmaceutical compounds for use in the therapy of clostridium difficile infection
AssigneeETH Zurich
InventorsBastien Castagner, Jean-Christophe Leroux, Mattias Ivarsson, Gisbert Schneider, Anna Pratsinis
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Abstract
The invention relates to a compound described by a general formula (1), wherein each X independently can be OPO32−, OPSO22− or OSO3−; R1 comprises a solubility function such as a polyethylene glycol moiety and each X independently can be OPO32−, OPSO22−, − or OSO3−; and Z is an alkyl chain comprising 1 to 3 carbon and/or hetero atoms. The invention further relates to polysulfate derivatives or mixed polyphosphate/sulphate derivatives of six-membered cyclic polyols for use in the therapy of infection by Clostridium difficile.
Claims20
A compound described by a general formula (1)
- wherein
- R1 comprises a solubility function R2 selected from the group including
- a polyethylene glycol;
- a monosaccharide, oligosaccharide or polysaccharide,
- a polyglycerol,
- a polymer or copolymer comprising a plurality of any of the monomers hydroxypropyl methacrylamide (HPMA), hydroxyethyl methacrylate (HEMA), vinyl alcohol (VA), vinyl pyrrolidone (VP), N-isopropyl acrylamide (NIPAM) and/or PEG methacrylate (PEGMA)
- with n and m independently having a value from 3 to 200;
- a poly(styrene-co-maleic acid/anhydride)
- a C3-C10 alkyl comprising at least three substituent functions independently selected from the group including an amine-, hydroxy-, thiol-, carboxylic acid, carboxylic amide, sulfonic acid or sulfonamide function,
- each X independently is selected from OPO32−, OPSO22−, − or OSO3−;
- and
- Z is an alkyl chain comprising 1 to 3 carbon and/or hetero atoms.
A compound described by a general formula (15)
- wherein each X independently is selected from OPO32−, OPSO22−, or OSO3−, with the proviso that not all X are OPO32− and not all X are OSO3−.
(canceled)
(canceled)
A method for therapy or prevention of Clostridium difficile infection, comprising administering to a subject in need thereof an inositol hexasulfate.
Dependencies are inferred from the claim text.