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US 2014/0235585 A1Published application
Substituted diaryl derivatives as sphingosine receptor modulators
AssigneeAllergan, Inc.
InventorsJanet A. Takeuchi, Ling Li, Wha Bin Im, KEN CHOW
Life of this patent
Estimating the term…
Abstract
The present invention relates to substituted diaryl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
Claims14
A compound represented by Formula I, its enantiomers, diastereoisomers, tautomers, or a pharmaceutically acceptable salt thereof,
- wherein:
- R1 is H, halogen or optionally substituted C1-6 alkyl;
- R2 is H, halogen or optionally substituted C1-6 alkyl;
- R3 is H, halogen or optionally substituted C1-6 alkyl;
- R4 is H, halogen or optionally substituted C1-6 alkyl;
- R5 is H, halogen or optionally substituted C1-6 alkyl;
- R6 is H, halogen or optionally substituted C1-6 alkyl;
- R7 is H, halogen or optionally substituted C1-6 alkyl;
- R8 is H, halogen or optionally substituted C1-6 alkyl;
- R9 is H, halogen or optionally substituted C1-6 alkyl;
- R10 is H, halogen or optionally substituted C1-6 alkyl,
- R11 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R15, NR16R17 or OR18;
- R12 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R15, NR16R17 or OR18;
- R13 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R15, NR16R17 or OR18;
- R14 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R15, NR16R17 or OR18;
- R15 is H, OH or optionally substituted C1-6 alkyl;
- R16 is H or optionally substituted C1-6 alkyl;
- R17 is H or optionally substituted C1-6 alkyl;
- R18 is H or optionally substituted C1-6 alkyl;
- a is 1, 2 or 3;
- X is CR16 or N;
- Y is CR16, O, S, NR16, CR16R17 or N;
- Z is CR16R17, NR16, CR16, N, O or S;
- W is OPO3H2, carboxylic acid, PO3H2, —P(O)MeOH, —P(O)(H)OH or OR18;
- and
- with proviso:
- a). when
- then
- X is CR16 or N;
- and
- Y is CR16 or N;
- and
- Z is CR16R17, NR16, O or S;
- and
- with proviso:
- b) when
- then
- X is CR16 or N;
- and
- Y is O, S, NR16 or CR16R17;
- and
- Z is CR16 or N.
39 more elements
A method of treating a disorder associated with sphingosine-1-phosphate receptor modulation, which comprises administering to a mammal in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of at least one compound of Formula I
- wherein:
- R1 is H, halogen or optionally substituted C1-6 alkyl;
- R2 is H, halogen or optionally substituted C1-6 alkyl;
- R3 is H, halogen or optionally substituted C1-6 alkyl;
- R4 is H, halogen or optionally substituted C1-6 alkyl;
- R5 is H, halogen or optionally substituted C1-6 alkyl;
- R6 is H, halogen or optionally substituted C1-6 alkyl;
- R7 is H, halogen or optionally substituted C1-6 alkyl;
- R8 is H, halogen or optionally substituted C1-6 alkyl;
- R9 is H, halogen or optionally substituted C1-6 alkyl;
- R10 is H, halogen or optionally substituted C1-6 alkyl;
- R11 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R15, NR16R17 or OR18;
- R12 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R15, NR16R17 or OR18;
- R13 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R15, NR16R17 or OR18;
- R14 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R15, NR16R17 or OR18;
- R15 is H, OH or optionally substituted C1-6 alkyl;
- R16 is H or optionally substituted C1-6 alkyl;
- R17 is H or optionally substituted C1-6 alkyl;
- R18 is H or optionally substituted C1-6 alkyl;
- a is 1, 2 or 3;
- X is CR16 or N;
- Y is CR16, O, S, NR16, CR16R17 or N;
- Z is CR16R17, NR16, CR16, N, O or S;
- W is OPO3H2, carboxylic acid, PO3H2, —P(O)MeOH, —P(O)(H)OH or OR18;
- and
- with proviso:
- a). when
- then
- X is CR16 or N;
- and
- Y is CR16 or N;
- and
- Z is CR16R17, NR16, O or S;
- and
- with proviso:
- b) when
- then
- X is CR16 or N;
- and
- Y is O, S, NR16 or CR16R17;
- and
- Z is CR16 or N.
39 more elements
Dependencies are inferred from the claim text.