Hiv replication inhibitors

A compound represented by the following Formula I:

• wherein B is selected from the group consisting of substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl;
• W is O, S, or NR;
• Y is a linker moiety selected from the group consisting of a direct bond, O, S, NR, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C1-C8 alkoxy, C1-C8 thioalkyl, C1-C8 alkylNR;
• R, R1, R2, and R3 are each individually selected from the group consisting of H, C1-C8 alkyl, C1-C8 haloalkyl, C1-C8 alkylaryl, C2-8 alkenyl, C2-8 alkynyl, cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or heterocycle;
• X is
• D and E are each individually selected from the group consisting of O, S, NR9, CR or CR1R2;
• R9 is selected from the group consisting of H, C1-C8 alkyl, C1-C8 haloalkyl, C3-C8 cycloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C5-C10 aryl, C5-C10 heterocycle each of which is optionally substituted with halogen, —OR10, —NR11R12, —SR11, —S(O)R11, —S(O)2R12, or —S(O)2NR11R12;
• R4, R5, R6, R7, and R8 are each are independently selected from H, hydroxyl, halogen, cyano, NO2, —OR10, —SR11, —S(O)R11, —S(O)2R12, —S(O)2NR11R12, C1-C8 haloalkyl, COR13, —C(O)OR12, —C(O)NR11R12, —C(O)R12, —NR11R12, —NR11C(O)R12, —NR11S(O)2R12, C(O)OR12, —B(OH)2, C1-C8 alkyl, C3-C8 cycloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, -alkylC(O)—OR12, -alkylC(O)NR11R12, -alkenylC(O)OR12, -alkenylC(O)NR11R12, -aryl(CH2)mC(O)OR12, -aryl(CH2)mX(O)NR11R12,
• —(CH2)mC(O)NR11S(O)2R12, -aryl(CH2)m—C(O)NR11S(O)2R12, —(CH2)mS(O)2NR11C(O)R12, -aryl(CH2)mS(O)2NR11C(O)R12, or substituted or unsubstituted heterocycle or substituted or unsubstituted heteroaryl containing 1 to 4 heteroatoms, optionally substituted with 1 to 2 substituents selected from the group consisting of H, hydroxyl, halogen, CF3, C1-C8 alkyl, C1-C8 alkoxy, cyano, amino, C1-C8 alkylamino, and C1-C8 alkoxyC1-C8 alkylamino provided at least one of R4, R5, R6, R7, or R8 is other than hydrogen;
• R10, R11, R12, and R13 are each individually selected from the group consisting of H, C1-C8 alkyl, C1-C8 haloalkyl, C1-C8 alkylaryl, C2-8 alkenyl, C2-8 alkynyl, cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or heterocycle;
• m=0 to 6;
• wherein alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocycle may be substituted or unsubstituted;
• pharmaceutically acceptable salt thereof;
• solvate thereof and deuterated form thereof.