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US 2014/0235573 A1Published application
Prevention and/or treatment of cancer and/or cancer metastasis
AssigneeThe University of Liverpool
InventorsJeremy Ewan Turnbull, Edwin Alexander Yates, Jonathan Michael Rhodes, Lu-Gang Yu
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Abstract
The present invention relates to the use of heparin derivatives for the prevention and/or treatment of cancer and/or cancer metastasis. The heparin derivatives are substantially 2-O and/or 6-O desulphated heparins which function as inhibitors of galectin-3 activity.
Claims15
A heparin derivative comprising one or more disaccharide units comprising a uronate moiety linked to a glucosamine moiety, and wherein:
- (i) the 2-O atom of the uronate moiety and/or the 6-O atom of the glucosamine moiety are substantially desulphated;
- and
- (ii) the heparin derivative exhibits less than 1% of the Anti-Factor Xa activity of unmodified porcine intestinal mucosal heparin;
- or a pharmaceutically acceptable salt or solvate thereof.
1 more element
Dependencies are inferred from the claim text.