Gemcitabine amide derivative and preparation method and use thereof
OwnerYunlong Song, Zhiyu Shaoinventors
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Abstract
The present invention relates to the field of medical technology, and in particular relates to a kind of gemcitabine amide derivative with a novel structure. The new compounds of the present invention are very active with regard to many tumour cells such as human lung cancer, colon cancer, breast cancer and liver cancer etc., and therefore can be used for preparing anti-tumour drugs. In addition, these compounds also have anti-viral activity. Also disclosed are a preparation method for the compounds, a pharmaceutical composition containing the compounds and the use thereof in preparing drugs against tumours and viruses etc.
Claims14
1-11. (canceled)
A gemcitabine amide derivative of the general formula (I), or the pharmaceutically acceptable salt, solvate or polymorph thereof:
- wherein, R is a substituted or non-substituted C1-21 straight-chain or branched alkyl, with the proviso that n-butyl, 1-propylbutyl, n-undecyl and n-heptadecyl are excluded;
- R can also be C1-8 alkyl directly connected with the substituted phenyl;
- the “substituted” refers to being substituted by one or more of the following substituents:
- hydrogen, C1-6 alkyl, C1-6 haloalkyl, C2-5 alkenyl, C2-5 alkynyl, C1-5 alkyloxy, halogen, nitro, cyano, hydroxyl, amino, carboxyl, and oxo.
A use of a gemcitabine amide derivative of the general formula (I) in the preparation of antitumor or antiviral agents, wherein, R is n-butyl.
A composition, comprising a safe and effective amount of a gemcitabine amide derivative of the general formula (I), and a pharmaceutically acceptable carrier, wherein, R is n-butyl.
Dependencies are inferred from the claim text.