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US 2014/0235565 A1Published application
N-alkylthio beta-lactams, alkyl-coenzyme a asymmetric disulfides, and aryl-alkyl disulfides as anti-bacterial agents
AssigneeUniversity of South Florida
InventorsEDWARD TUROS, KEVIN D. REVELL
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Abstract
The present invention provides N-alkylthio β-lactams and disulfide compounds (e.g., alkyl-coenzyme A asymmetric disulfides or aryl-alkyl disulfides), compositions containing such compounds, and methods of their use as anti-bacterial agents.
Claims10
A compound having a chemical structure selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof, wherein R and R′ are the same or different, each being independently selected from the group consisting of H, alkyl, cycloalkyl, alkoxy, aryl, heteroaryl, heteroalkyl, alkanoyl, 2-aminoalkyl, 2-hydroxyalkyl, and halo;
- or
- a composition comprising said compound and a pharmaceutically acceptable carrier.
A method for
- i) treating or preventing a Bacillus anthracis infection, comprising administering to a subject in need thereof an effective amount of an N-alkylthio beta-lactam;
- or
- ii) inhibiting the growth of Bacillus anthracis, comprising contacting the B. anthracis with an effective amount of an N-alkylthio beta-lactam;
- or applying the N-alkylthio beta-lactam to a surface that may come in contact with the B. anthracis.
1 more element
A compound having the chemical structure I,
- or a pharmaceutically acceptable salt thereof, wherein A and B are each electron withdrawing groups and are the same or different, and wherein R is selected from the group consisting of H, alkyl, cycloalkyl, alkoxy, aryl, heteroaryl, heteroalkyl, alkanoyl, 2-aminoalkyl, 2-hydroxyalkyl, and halo;
- or
- a compound having the chemical structure II, or a pharmaceutically acceptable salt thereof,
- wherein A and B are each electron withdrawing groups, wherein Y is the same or different and is independently selected from the group consisting of carbon, nitrogen, and oxygen, and wherein R is selected from the group consisting of H, alkyl, cycloalkyl, alkoxy, aryl, heteroaryl, heteroalkyl, alkanoyl, 2-aminoalkyl, 2-hydroxyalkyl, and halo;
- or
- a compound having the chemical structure III, or a pharmaceutically acceptable salt thereof,
- wherein A and B are each electron withdrawing groups, wherein Y is the same or different and is independently selected from the group consisting of carbon, nitrogen, oxygen, and sulfur, and wherein R is selected from the group consisting of H, alkyl, cycloalkyl, alkoxy, aryl, heteroaryl, heteroalkyl, alkanoyl, 2-aminoalkyl, 2-hydroxyalkyl, and halo;
- or
- a composition comprising said compound and a pharmaceutically acceptable carrier.
6 more elements
Dependencies are inferred from the claim text.