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AssigneeHanall Biopharma Co., Ltd.
InventorsSung-Wuk Kim, Sung-Soo Jun, Chang-Hee Min, Ja-Seong Koo, Jin-Wook Kim, Yong-Eun Kim, Sang-Ouk Sun
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Disclosed is an anticancer pharmaceutical composition comprising phenformin or a pharmaceutically acceptable salt thereof, and 2-deoxy-D-glucose as active ingredients. These ingredients act in synergy with each other, thus exhibiting more potent inhibitory activity against the growth of cancer cells, compared to individual ingredients. Also, the synergistic anticancer activity allows the individual drugs to be used in lower amounts, which leads to a reduction in the occurrence of adverse effects. In addition, the time-lag release or administration of the ingredients decreases blood lactic acid levels to significantly mitigate the adverse effect of lactic acidosis, as well as exerting high anticancer effects. Particularly, the pharmaceutical composition can be formulated to dosage forms effective for therapy, increasing the drug compliance of the subject.
A pharmaceutical composition for preventing or treating cancer comprising phenformin or a pharmaceutically acceptable salt thereof and 2-deoxy-D-glucose, as active ingredients.
A pharmaceutical composition for preventing or treating cancer comprising phenformin or a pharmaceutically acceptable salt thereof and 2-deoxy-D-glucose, as active ingredients, characterized in that the 2-deoxy-D-glucose is released in advance of phenformin or a pharmaceutically acceptable salt thereof.
A method for preventing or treating cancer comprising administering an effective amount of a pharmaceutical composition comprising phenformin or a pharmaceutically acceptable salt thereof and 2-deoxy-D-glucose, as active ingredients.
A method for preventing or treating cancer, characterized in that 2-deoxy-D-glucose is administered to a subject in advance of phenformin or a pharmaceutically acceptable salt thereof.
A method for preventing or treating cancer, characterized in that a pharmaceutical composition comprises an immediate release dosage form of 2-deoxy-D-glucose and a delayed-release dosage form of phenformin or a pharmaceutically acceptable salt thereof is administered.
Dependencies are inferred from the claim text.