Compositions and methods of treating gliomas

A composition for treating or ameliorating the effects of a glioma comprising a pharmaceutically acceptable carrier, a first active agent selected from the group consisting of an angiotensin receptor blocker, an antifungal agent, a bisphosphonate, an oxytocin inhibitor, an interleukin-1 (IL-1) inhibitor, a cyclooxygenase inhibitor, an α2δ voltage-dependent calcium channel (VDCC) inhibitor, a dihydroorotate dehydrogenase inhibitor, a calcium channel blocker, a renal sodium-chloride symporter inhibitor, an α2 adrenergic agonist, a phenothiazine antipsychotic, a calcineurin inhibitor, a 5-HT agonist, an angiotensin-converting enzyme (ACE) inhibitor, a direct rennin inhibitor, and combinations thereof, and a second active agent, which is a chemotherapeutic agent.

A method for treating or ameliorating the effects of a glioblastoma comprising co-administering to a subject in need thereof an effective amount of a first active agent selected from the group consisting of candesartan, terbinafine, risedronate, atosiban, diacerein, paracetamol, pregabalin, leflunomide, amlodipine, quinethazone, tizanidine, promazine, cyclosporin A, sumatriptan, a prodrug thereof, a pharmaceutically acceptable salt thereof, and combinations thereof, and a second active agent, which is temozolomide, a prodrug thereof, or a pharmaceutically acceptable salt thereof.

A composition comprising a first active agent selected from the group consisting of an angiotensin receptor blocker, an antifungal agent, a bisphosphonate, an oxytocin inhibitor, an interleukin-1 (IL-1) inhibitor, a cyclooxygenase inhibitor, an α2δ voltage-dependent calcium channel (VDCC) inhibitor, a dihydroorotate dehydrogenase inhibitor, a calcium channel blocker, a renal sodium-chloride symporter inhibitor, an α2 adrenergic agonist, a phenothiazine antipsychotic, a calcineurin inhibitor, a 5-HT agonist, an angiotensin-converting enzyme (ACE) inhibitor, a direct rennin inhibitor, and combinations thereof, and a second active agent, which is temozolomide, a prodrug thereof, or a pharmaceutically acceptable salt thereof;

• and a pharmaceutically acceptable carrier.

A composition comprising a pharmaceutically acceptable carrier, a first active agent selected from the group consisting of candesartan, terbinafine, risedronate, atosiban, diacerein, paracetamol, pregabalin, leflunomide, amlodipine, quinethazone, tizanidine, promazine, cyclosporin A, sumatriptan, a prodrug thereof, a pharmaceutically acceptable salt thereof, and combinations thereof, and a second active agent, which is temozolomide, a prodrug thereof, or a pharmaceutically acceptable salt thereof.