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US 2014/0235542 A1Published application
Modular, bioactive peptides for binding native bone and improving bone graft osteoinductivity
AssigneeWisconsin Alumni Research Foundation
InventorsSheeny K.L. Levengood, Sabrina H. Brounts, William L. Murphy, Jae Sung Lee
Life of this patent
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Abstract
A modular peptide design strategy wherein the modular peptide has two functional units separated by a spacer portion is disclosed. More particularly, the design strategy combines a bone-binding portion and a biomolecule-derived portion. The modular peptides have improved non-covalent binding to the surface of native bone, and are capable of initiating osteogenesis, angiogenesis, and/or osteogenic differentiation.
Claims13
A method of coating native bone with a modular peptide, the method comprising:
- exposing native bone to a solution comprising a modular peptide, wherein the native bone is selected from the group consisting of a bone autograft, a bone allograft, and a bone xenograft, wherein the modular peptide comprises a bone-binding portion and a biomolecule-derived portion and wherein the modular peptide is non-covalently bound to the native bone.
(canceled)
13-20. (canceled)
Dependencies are inferred from the claim text.