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US 2014/0235538 A1Published application
Stabilized Insulin-like Growth Factor Polypeptides
AssigneeNovartis AG
InventorsDavid Jonathan GLASS, Mara FORNARO
Life of this patent
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Abstract
The invention relates to stabilized polypeptides having an IGF-1 or IGF-2 sequence and an E-peptide sequence, where the natural physiological cleavage of the E-peptide from the IGF is prevented.
Claims17
A polypeptide comprising the sequence of any one of SEQ ID NO:
- 8-84.
A method of treating a musculoskeletal disease, diabetes, neuronal cell death, or anemia, the method comprising the step of administering a therapeutically effective amount of a polypeptide comprising the sequence of any one of SEQ ID NO:
- 8-84 to a subject in need thereof.
A method of increasing muscle mass in a subject, the method comprising the step of:
- Administering to the subject a therapeutically effective amount of a polypeptide comprising the sequence of any one of SEQ ID NO:
- 8-84.
Dependencies are inferred from the claim text.