Spray Drying Vancomycin
AssigneeHospira, Inc.
InventorsCynthia Fragale, Daniel Brueck
Life of this patent
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Abstract
A method and formulation for preparing spray dried vancomycin. In various embodiment, the formulation includes vancomycin HCl (10-20%) and one or more of the following PEG (0-5%), mannitol (0-5%), ethanol (0-10%), and a citrate buffer. Spray dried vancomycin has favorable reconstitution times and water content.
Claims18
A method for preparing a powdered vancomycin pharmaceutical product for injection, the method comprising:
- providing a solution comprising about 15% weight vancomycin, about 2.5% by weight mannitol and about 2.5% by weight polyethylene glycol (PEG);
- and
- spray drying the solution to form a powdered vancomycin pharmaceutical product.
A powdered vancomycin pharmaceutical product produced by spray-drying a liquid containing vancomycin, polyethylene glycol, and mannitol, the powdered vancomycin pharmaceutical product comprising about 75% by weight vancomycin, about 12.5% by weight mannitol, and about 12.5% by weight polyethylene glycol, and less than about 2.0% by weight water.
A method for reducing the loss of vancomycin in a spray-drying process, the method comprising:
- combining vancomycin, mannitol, and polyethylene glycol (PEG) to form an aqueous solution containing approximately 15% by weighet vancomycin, about 2.5% by weight mannitol, and about 2.5% by weight PEG,
- spray drying the aqueous solution to form a powder, wherein less than about 2% of vancomycin contained in the aqueous solution is degraded during spray drying.
Dependencies are inferred from the claim text.