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US 2014/0235526 A1Published application
Methods for Generating Cardiomyocytes
AssigneeThe J. David Gladstone Institutes
InventorsDeepak Srivastava, Masaki Ieda
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Abstract
The present disclosure provides method of generating cardiomyocytes from post-natal fibroblasts. The present disclosure further provides cells and compositions for use in generating cardiomyocytes.
Claims14
An in vivo method of generating an induced cardiomyocyte, the method comprising:
- introducing into a post-natal fibroblast one or more reprogramming factors selected from Gata4, Mef2c, Tbx5, Mesp1, Nkx2-5, Isl-1, Myocd, Smyd1, and Srf polypeptides, wherein said introducing results in direct reprogramming of the post-natal fibroblast into a cardiomyocyte, thereby generating an induced cardiomyocyte.
11-35. (canceled)
Dependencies are inferred from the claim text.