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US 2014/0235511 A1Published application
Molecular profiling of tumors
AssigneeCaris MPI, Inc.
InventorsDaniel D. Von Hoff, David M. Loesch, Arlet Alarcon, Robert J. Penny, Alan Wright, Matthew J. McGinniss, Ryan P. Bender, Traci Pawlowski
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Abstract
Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.
Claims21
A system for generating a report identifying a therapeutic agent for an individual with colorectal cancer comprising:
- a. one or more computer database comprising:
- i. a reference value for a plurality of molecular targets;
- ii. a listing of available therapeutic agents for said plurality of molecular targets;
- b. a computer-readable program code for inputting individualized molecular profile test values obtained for molecular targets comprising PTEN and RRM1 in a biological sample from the individual and comparing said test values with a corresponding reference value in (a)(i);
- c. a computer-readable program code for accessing the database in (a) and identifying one or more therapeutic agent if present in (a)(ii) for the molecular targets wherein said comparison to said reference in (b) indicates a likely benefit of the one or more therapeutic agent;
- and
- d. a computer-readable program for generating a report that comprises a listing of all the molecular targets exhibiting a change in (b) and the one or more therapeutic agent identified in (c).
4 more elements
Dependencies are inferred from the claim text.