Back to results
US 2014/0235489 A1Published application
Integrated Membrane Sensor
AssigneeDiagnostic Biosensors, LLC
InventorMark Christopher Tondra
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeDiagnostic Biosensors, LLC
InventorMark Christopher Tondra
Estimating the term…
An integrated microelectronic sensor is provided in a disposable flow membrane sensing device. The integrated sensors detect electromagnetic effect labels in flow detection zones above the sensor in the membrane. The labels are small particles that give off a detectable electromagnetic signal. They are commonly used for isolating and quantifying biochemical targets of interest. The sensors are fabricated using planar integrated circuit technologies. Sensors can detect labels of several types including magnetic, electric, and photonic. These types all have in common the fact that the sensor detects the label at a distance. Magnetoresistive sensors for detecting magnetic labels, and photodiodes for detecting photonic labels are described. A system for using the sensors is described. There are disposable cartridges with a backing that supports the sensors and membrane is described. The integrated sensor in the cartridge is designed to be discarded after use. Also, label excitation sources are provided. The multi sensor array chip can be configured in order to detect labels in multiple zones, and to monitor progress of flow down a strip of membrane. These multiple label detection zones, using sandwich assay techniques, can quantify analyte concentration for many types of analytical samples. Also, the membrane can be micropatterned in order to provide multiple or unusually shaped flow paths.
An electromagnetic effect system to detect labels in a fluid comprising:
The system of claim 8 further comprising:
The system of claim 9 wherein the second electrical interconnects are spring-loaded.
The system of claim 9 further comprising an electromagnetic effect field excitation source within the system fixture capable of generating an electromagnetic effect field at the electromagnetic effect field sensor when the cartridge is positioned within the slot of the system fixture.
A method for detecting the concentration of labels in a fluid comprising:
The method of claim 12 wherein the labels are concentrated in the label detection zone by selective binding of the labels to a label capture site disposed substantially within the label detection zone.
The method of claim 12 wherein the labels are partially excluded from the label detection zone by selective competitive unbinding of the labels to a label capture site disposed substantially within the label detection zone.
The method of claim 12 further comprising:
Dependencies are inferred from the claim text.